{"id":"W4324057774","doi":"10.25251/skin.7.supp.111","title":"Durability of Efficacy and Safety of Roflumilast Cream 0.3% in Adults With Chronic Plaque Psoriasis From a 52-Week, Phase 2 Open-Label Safety Trial","year":2023,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Probity Medical Research; University of British Columbia; Queen's University","funders":"","keywords":"Medicine; Tolerability; Adverse effect; Cohort; Roflumilast; Internal medicine; Psoriasis; Randomized controlled trial; Open label; Surgery; Dermatology; COPD","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002576355,0.0002383401,0.001328888,0.0001424122,0.0001006836,0.00000648273,0.0003657409,0.00009706446,0.0003312099],"category_scores_gemma":[0.002481898,0.000123032,0.00006036066,0.0006184215,0.0006401175,0.0001209069,0.0001658704,0.0007206948,0.000002273718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001395887,"about_ca_system_score_gemma":0.000291076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009619907,"about_ca_topic_score_gemma":0.0004360074,"domain_scores_codex":[0.9968469,0.0004329906,0.001454426,0.0002162855,0.0007447278,0.0003046645],"domain_scores_gemma":[0.9929587,0.005103115,0.001078477,0.0003322314,0.0002900855,0.0002373639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9273454,0.004411357,0.0006507384,0.000435212,0.001037725,0.0008935079,0.004911143,0.00008208703,0.004323584,0.00002626714,0.001450573,0.05443244],"study_design_scores_gemma":[0.828167,0.1076731,0.01332383,0.009735316,0.003636124,0.004330417,0.005563332,0.001341487,0.004134323,0.0004710797,0.02122217,0.0004017713],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806349,0.003905123,0.00003649696,0.0129112,0.0003386021,0.001224586,0.00006080843,0.000009066797,0.0008792478],"genre_scores_gemma":[0.9798016,0.01915753,0.0001014801,0.0001732904,0.0006770929,0.000004133795,0.00001136763,0.00002147151,0.00005201773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1032618,"threshold_uncertainty_score":0.5017101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05145775588564373,"score_gpt":0.3755849522784312,"score_spread":0.3241271963927875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}