{"id":"W4324064994","doi":"10.3390/cancers15061735","title":"Aberrant HMGA2 Expression Sustains Genome Instability That Promotes Metastasis and Therapeutic Resistance in Colorectal Cancer","year":2023,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"University of Manitoba","keywords":"HMGA2; Colorectal cancer; Genome instability; Metastasis; Cancer research; Microsatellite instability; Cancer; Genome; Medicine; Biology; Oncology; Internal medicine; Genetics; Gene; DNA; microRNA; DNA damage; Microsatellite","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002052087,0.0002264916,0.000408575,0.0006230004,0.0001578543,0.0005176555,0.0002524894,0.0003944476,0.001081172],"category_scores_gemma":[0.0002321123,0.0001172286,0.0003337732,0.0004185865,0.0001705144,0.0003495219,0.000285423,0.0004544305,0.0004617255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004223782,"about_ca_system_score_gemma":0.0004230603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006195682,"about_ca_topic_score_gemma":0.001117745,"domain_scores_codex":[0.9998951,0.00002038526,0.0000140431,0.00001567648,0.00003374743,0.000021027],"domain_scores_gemma":[0.9999311,0.00001726435,0.00002083342,0.000002559037,0.00001702484,0.00001111968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007834453,0.0001050978,0.009404077,0.01720786,0.0005084582,0.004258729,0.0006692487,0.00109893,0.4599322,0.007574521,0.01904972,0.4794078],"study_design_scores_gemma":[0.00008878436,0.000895569,0.05006257,0.002254651,0.0008496131,0.01624089,0.0006966761,0.00113622,0.1250051,0.003320871,0.7993395,0.0001096182],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0391918,0.9532388,0.0009967277,0.0008168986,0.0002324089,0.00003292081,0.000331441,0.00007972472,0.00507933],"genre_scores_gemma":[0.1993705,0.7923339,0.001284288,0.0007459176,0.0003708138,0.00006114931,0.0009417819,0.00001738517,0.004874219],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001081172,"threshold_uncertainty_score":0.003616869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05682103760716751,"score_gpt":0.3537136708242142,"score_spread":0.2968926332170467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}