{"id":"W4324085227","doi":"10.1101/2023.03.09.531873","title":"Senescence during early differentiation reduced chondrogenic differentiation capacity of mesenchymal progenitor cells","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Delta; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Arthritis Society; Dutch Arthritis Society","keywords":"Chondrogenesis; Mesenchymal stem cell; Senescence; Cell biology; Cartilage; Paracrine signalling; Progenitor cell; Cellular differentiation; Biology; Chemistry; Stem cell; Anatomy; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002843661,0.0003212337,0.0002871405,0.000279882,0.0001184786,0.0003364286,0.0001355645,0.0002123317,0.001653997],"category_scores_gemma":[0.000224536,0.0001411534,0.0002963448,0.0001639833,0.0001765158,0.0001789933,0.0002740664,0.0004338172,0.0006544717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001435084,"about_ca_system_score_gemma":0.0002780744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004184792,"about_ca_topic_score_gemma":0.0002719806,"domain_scores_codex":[0.9998189,0.00003736092,0.00002700755,0.00003104077,0.00005634201,0.00002927653],"domain_scores_gemma":[0.9998009,0.00004520418,0.00003049345,0.00003408509,0.00005164134,0.00003777822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006881959,0.000009966781,0.0002304481,0.00003368999,0.000002586445,0.00003366677,0.00002072566,0.00002806774,0.9984131,0.00005348412,0.00002014442,0.001085274],"study_design_scores_gemma":[0.00000672308,0.0002160318,0.004310721,0.000008994553,0.00001084124,0.000225617,0.00002779433,0.0004665339,0.9913492,0.00006323225,0.0033112,0.000003227514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865385,0.004119558,0.006669624,0.00008752223,0.00007545874,0.00003046544,0.0005483587,0.00008376348,0.001846798],"genre_scores_gemma":[0.9898018,0.001716705,0.00230761,0.00008211591,0.00002560556,0.00003781612,0.001114866,0.00004484749,0.004868526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001653997,"threshold_uncertainty_score":0.005533159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03416645314198884,"score_gpt":0.2519862842437174,"score_spread":0.2178198311017285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}