{"id":"W4324116853","doi":"10.1016/j.gimo.2023.100107","title":"P088: What's trending: Comparing variant of uncertain significance (VUS) rates in cancer predisposition genes over time in Black and White individuals","year":2023,"lang":"en","type":"article","venue":"Genetics in Medicine Open","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"White (mutation); Genetics; Gene; Cancer; Biology; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001057477,0.0002096529,0.0003532286,0.001173396,0.0003987096,0.0008434774,0.0006713712,0.0007521521,0.003666801],"category_scores_gemma":[0.005505589,0.0001580403,0.0006773572,0.001595163,0.0003841364,0.0005191138,0.0005347938,0.0005770827,0.0005146867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002167337,"about_ca_system_score_gemma":0.0002354685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009208944,"about_ca_topic_score_gemma":0.008324414,"domain_scores_codex":[0.9988698,0.0001727002,0.00007357929,0.0006283561,0.0001230028,0.0001325029],"domain_scores_gemma":[0.996371,0.001305454,0.001335133,0.0003692126,0.000278261,0.0003408812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000563869,0.00001271168,0.9883647,0.00005565486,0.0004230461,0.0002243757,0.0001862041,0.0001529555,0.0009856587,0.00008050011,0.00120813,0.007742267],"study_design_scores_gemma":[0.00001456314,0.0001015684,0.9956002,0.00002600846,0.0002123564,0.001120142,0.000266087,0.0006303707,0.0002527086,0.0002166513,0.001548818,0.00001044729],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908333,0.001077969,0.0008283799,0.0001892555,0.00003124283,0.00001066747,0.006174948,0.00004557356,0.0008085067],"genre_scores_gemma":[0.9963613,0.0001711751,0.0004018494,0.00006664018,0.00002951854,0.00001390581,0.002623665,0.00003641583,0.0002953511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009208944,"threshold_uncertainty_score":0.01831067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04349671234305855,"score_gpt":0.3629489396664533,"score_spread":0.3194522273233947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}