{"id":"W4324121660","doi":"10.17816/phf120109","title":"Molecular mechanisms of transport of substances across the blood-brain barrie as targets for pharmacological action. Part 2. Modern methods of delivery of pharmacological agents to the central nervous system","year":2023,"lang":"en","type":"article","venue":"Pharmacy Formulas","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Blood–brain barrier; Drug delivery; Site of action; Neuroscience; Central nervous system; Drug delivery to the brain; Drug; Medicine; Pharmacology; Biology; Nanotechnology; Materials science","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002333594,0.0007836591,0.0006560623,0.000764563,0.0003948738,0.001063685,0.0008953392,0.00136914,0.004051379],"category_scores_gemma":[0.0001759595,0.0003938038,0.0006237823,0.0003822864,0.001141527,0.001642595,0.0003566721,0.001289038,0.002391179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008187258,"about_ca_system_score_gemma":0.0005900155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005448184,"about_ca_topic_score_gemma":0.0003871027,"domain_scores_codex":[0.9998541,0.00002913973,0.00001058893,0.00003331329,0.00005006204,0.00002271058],"domain_scores_gemma":[0.9999292,0.00002070255,0.00002269274,0.000005476053,0.00001430163,0.000007707493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002842434,0.0002075943,0.0004475599,0.008946879,0.0001493195,0.001606626,0.000331011,0.002728284,0.4666324,0.1903722,0.02799247,0.3003015],"study_design_scores_gemma":[0.00004977786,0.0008432859,0.005257755,0.0006458844,0.0001393622,0.004686253,0.00022723,0.003713832,0.2195449,0.0559837,0.708799,0.0001090318],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01390074,0.9042842,0.04439706,0.004600678,0.002166046,0.0001713385,0.0005251401,0.0004104643,0.02954436],"genre_scores_gemma":[0.1070816,0.8188784,0.01826407,0.002222178,0.001312808,0.0005022335,0.0007072207,0.00006398727,0.05096753],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004051379,"threshold_uncertainty_score":0.01355326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05143471617596398,"score_gpt":0.3620148191321123,"score_spread":0.3105801029561484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}