{"id":"W4324129207","doi":"10.1021/acsinfecdis.2c00549","title":"Chimeric Tobramycin-Based Adjuvant TOB-TOB-CIP Potentiates Fluoroquinolone and β-Lactam Antibiotics against Multidrug-Resistant <i>Pseudomonas aeruginosa</i>","year":2023,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Institute of Infection and Immunity; Canadian Institutes of Health Research","keywords":"Tobramycin; Aztreonam; Microbiology; Pseudomonas aeruginosa; Efflux; Antibiotics; Acinetobacter baumannii; Ciprofloxacin; Imipenem; Antibiotic resistance; Biology; Bacteria; Gentamicin; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008983468,0.000344318,0.0002671237,0.0001604139,0.0001084748,0.0002627581,0.0002135967,0.000350139,0.001161524],"category_scores_gemma":[0.0001002553,0.0001094282,0.0003203218,0.0001235467,0.0001874834,0.0001996191,0.0002409124,0.0006002405,0.0004910644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003747435,"about_ca_system_score_gemma":0.0003039948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009336091,"about_ca_topic_score_gemma":0.0009629889,"domain_scores_codex":[0.9998779,0.00001725746,0.000007774793,0.00002446374,0.00003357633,0.00003903292],"domain_scores_gemma":[0.9999384,0.000006066114,0.00002193546,0.000006271651,0.000007838503,0.00001953206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006035898,0.00001354243,0.00007532169,0.00001874914,0.000003398657,0.00001935473,0.000005208375,0.0001084269,0.9989483,0.00006971574,0.0000283018,0.0006492736],"study_design_scores_gemma":[0.00001439273,0.0002672623,0.0007936441,0.000004870548,0.0000194712,0.0002164661,0.00001024004,0.0007335816,0.9925374,0.00002143156,0.005374942,0.000006230559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880989,0.001625268,0.007509213,0.0001954867,0.00004865075,0.00005466675,0.000340403,0.0002219092,0.00190546],"genre_scores_gemma":[0.9900566,0.0006219225,0.006458251,0.00008667322,0.000008525354,0.0000286947,0.0004402758,0.00003028644,0.002268782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001161524,"threshold_uncertainty_score":0.003885686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006362823278621018,"score_gpt":0.2307296149806269,"score_spread":0.2243667917020059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}