{"id":"W4324129207","doi":"10.1021/acsinfecdis.2c00549","title":"Chimeric Tobramycin-Based Adjuvant TOB-TOB-CIP Potentiates Fluoroquinolone and β-Lactam Antibiotics against Multidrug-Resistant <i>Pseudomonas aeruginosa</i>","year":2023,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Institute of Infection and Immunity; Canadian Institutes of Health Research","keywords":"Tobramycin; Aztreonam; Microbiology; Pseudomonas aeruginosa; Efflux; Antibiotics; Acinetobacter baumannii; Ciprofloxacin; Imipenem; Antibiotic resistance; Biology; Bacteria; Gentamicin; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001473082,0.0005108204,0.0004680275,0.0001847331,0.0003696508,0.0001567983,0.0003068337,0.0002610454,0.00001839673],"category_scores_gemma":[0.0003592947,0.0004993553,0.0002116748,0.0004523938,0.0004301861,0.00002153924,0.0002763391,0.0001669356,0.00007835102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004778097,"about_ca_system_score_gemma":0.0001764468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006137772,"about_ca_topic_score_gemma":0.00007273535,"domain_scores_codex":[0.9974318,0.0001411009,0.0004731758,0.0008911146,0.0003135402,0.0007493181],"domain_scores_gemma":[0.9984103,0.00009740239,0.0002408748,0.0007904962,0.000147806,0.0003131467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002434305,0.0003874915,0.3153802,0.0002037259,0.0002228965,0.0001112618,0.00002818345,0.0003515501,0.675898,0.000057603,0.003802389,0.003313345],"study_design_scores_gemma":[0.002944801,0.0006740876,0.7027206,0.0002138145,0.0003218483,0.0000284479,0.0002118291,0.0006902842,0.2851454,0.0001546986,0.005564461,0.00132964],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956688,0.001911289,0.0001737796,0.0001630797,0.0005173441,0.000478835,0.00034195,0.0003308944,0.0004139977],"genre_scores_gemma":[0.995324,0.002169715,0.0002029142,0.0006243993,0.0003033264,0.000009548577,0.001001348,0.0001040239,0.0002607463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3907525,"threshold_uncertainty_score":0.9997458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006362823278621018,"score_gpt":0.2307296149806269,"score_spread":0.2243667917020059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}