{"id":"W4324132216","doi":"10.1097/ftd.0000000000001085","title":"Role of Cisplatin Dose Intensity and TPMT Variation in the Development of Hearing Loss in Children","year":2023,"lang":"en","type":"article","venue":"Therapeutic Drug Monitoring","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; BC Children's Hospital; University of British Columbia","funders":"","keywords":"Ototoxicity; Cisplatin; Hearing loss; Thiopurine methyltransferase; Medicine; Cumulative dose; Dosing; Audiology; Common Terminology Criteria for Adverse Events; Internal medicine; Oncology; Adverse effect; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001052053,0.0001137759,0.000187267,0.0002140065,0.00006733984,0.00002066281,0.0002384762,0.00004517403,0.000001386842],"category_scores_gemma":[0.0001165252,0.0001014103,0.0000188976,0.0006777809,0.00005777731,0.00007290533,0.0001567147,0.0002073298,0.000005013981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004806394,"about_ca_system_score_gemma":0.00005655547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001940308,"about_ca_topic_score_gemma":0.00002331841,"domain_scores_codex":[0.9986358,0.0001463742,0.0004084258,0.0002410228,0.0003095994,0.0002587513],"domain_scores_gemma":[0.9993567,0.0002424567,0.0001144096,0.0002330721,0.00002704946,0.00002623953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002098068,0.0000387414,0.5602837,0.0000168762,0.000004546886,0.000001188809,0.02644595,0.0003699591,0.3994607,0.00005393081,1.234107e-7,0.01330331],"study_design_scores_gemma":[0.0002443245,0.000009767999,0.7541673,0.00006456788,0.00000348781,0.000003317951,0.0006367684,0.0008157581,0.2436552,0.0003249627,0.000005721267,0.00006886365],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993675,0.00007003878,0.00002583124,0.00005098162,0.0001005046,0.0002575712,8.686709e-7,0.00002706093,0.00009961906],"genre_scores_gemma":[0.9994243,0.00004797808,0.0004295185,0.00001818272,0.00004042349,0.00001093322,4.475734e-7,0.0000150578,0.00001320494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1938836,"threshold_uncertainty_score":0.4135393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0467471888648484,"score_gpt":0.2976313627238935,"score_spread":0.250884173859045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}