{"id":"W4324132617","doi":"10.1158/1078-0432.ccr-22-3291","title":"Treatment of Prostate Cancer with CD46-targeted 225Ac Alpha Particle Radioimmunotherapy","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; University of California, San Francisco; U.S. Department of Defense; U.S. Department of Energy; University of California, Davis; University of Alberta; DOD Prostate Cancer Research Program; School of Veterinary Medicine, University of California, Davis","keywords":"Radioimmunotherapy; Prostate cancer; Medicine; Cancer; Antibody; Immunotherapy; Cancer research; Oncology; Monoclonal antibody; Internal medicine; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005733136,0.0001215701,0.0003833455,0.0000456875,0.0001179757,0.00001317048,0.0001186571,0.00008874391,0.0008272266],"category_scores_gemma":[0.00008641389,0.0000819051,0.0001151036,0.001074216,0.0006347818,0.00003500122,0.00002425232,0.0003248946,0.00007527974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001663262,"about_ca_system_score_gemma":0.0005665634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003092494,"about_ca_topic_score_gemma":0.00001803367,"domain_scores_codex":[0.9980756,0.0001179346,0.0004340203,0.0003869611,0.0004917171,0.0004937567],"domain_scores_gemma":[0.998354,0.0005215438,0.00005994902,0.0004480161,0.0002964741,0.0003200537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0110819,0.002619475,0.5156575,0.0003909577,0.000962992,0.0001638606,0.0008731565,0.0001848586,0.2374098,0.0002531275,0.008854681,0.2215478],"study_design_scores_gemma":[0.0142397,0.004333268,0.1886148,0.0002385043,0.000176712,0.00001177023,0.0002934592,0.00326063,0.5318339,0.0001977833,0.2565232,0.0002762848],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814589,0.003629938,0.000002977954,0.01339568,0.00005170569,0.0008337569,0.00006522702,0.0000809636,0.0004808368],"genre_scores_gemma":[0.9705957,0.02004314,0.00006279815,0.0001306049,0.0003232621,0.001281274,0.00002453712,0.00003124922,0.007507457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3270427,"threshold_uncertainty_score":0.9057551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3407334570204403,"score_gpt":0.5932641462564825,"score_spread":0.2525306892360422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}