{"id":"W4324132617","doi":"10.1158/1078-0432.ccr-22-3291","title":"Treatment of Prostate Cancer with CD46-targeted 225Ac Alpha Particle Radioimmunotherapy","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; University of California, San Francisco; U.S. Department of Defense; U.S. Department of Energy; University of California, Davis; University of Alberta; DOD Prostate Cancer Research Program; School of Veterinary Medicine, University of California, Davis","keywords":"Radioimmunotherapy; Prostate cancer; Medicine; Cancer; Antibody; Immunotherapy; Cancer research; Oncology; Monoclonal antibody; Internal medicine; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001077706,0.0002863306,0.0002498202,0.0002255402,0.0001134157,0.0002548122,0.0002117747,0.0001888137,0.0007351086],"category_scores_gemma":[0.00006477806,0.00009531516,0.0003030433,0.0001956495,0.0001755304,0.0001466256,0.0001742231,0.0002878705,0.000314927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003671381,"about_ca_system_score_gemma":0.0002184721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007811923,"about_ca_topic_score_gemma":0.0007179289,"domain_scores_codex":[0.9999081,0.00001556336,0.00000507812,0.00002011633,0.00002894134,0.00002210519],"domain_scores_gemma":[0.9999776,0.000002046216,0.000008910363,0.000003120294,0.000002846639,0.000005472454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.0004927253,0.0002118262,0.001227498,0.0002606963,0.00005938113,0.0002079448,0.00004517694,0.001654171,0.9635515,0.0003343111,0.000421009,0.03153371],"study_design_scores_gemma":[0.0000929961,0.002755119,0.00729265,0.00001947234,0.0001009948,0.001854867,0.00002393769,0.004366384,0.9744626,0.00007611874,0.008939553,0.00001525966],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9678255,0.01515715,0.01287619,0.000168396,0.00005615881,0.0001288642,0.0001490649,0.0003085464,0.003330173],"genre_scores_gemma":[0.9921218,0.003248055,0.003135077,0.00006136898,0.00001971718,0.00002485509,0.000169263,0.00001600441,0.001203844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007811923,"threshold_uncertainty_score":0.002663791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3407334570204403,"score_gpt":0.5932641462564825,"score_spread":0.2525306892360422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}