{"id":"W4324135401","doi":"10.1016/j.nbd.2023.106082","title":"The contribution of Neanderthal introgression and natural selection to neurodegenerative diseases","year":2023,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Medical Research Council; King's College London; Motor Neurone Disease Association; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Economic and Social Research Council; South London and Maudsley NHS Foundation Trust","keywords":"Neanderthal; Biology; Introgression; Disease; Neurodegeneration; Amyotrophic lateral sclerosis; Evolutionary biology; Genetics; Population; Natural selection; Single-nucleotide polymorphism; Medicine; Pathology; Gene; Genotype; Geography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001980457,0.0004159914,0.0005015652,0.0007926131,0.0005009816,0.0008280416,0.0003997537,0.0003677569,0.001393944],"category_scores_gemma":[0.005804871,0.0001899906,0.0004672247,0.001015496,0.001032339,0.0005376824,0.0009070993,0.0004902808,0.0001417793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003201655,"about_ca_system_score_gemma":0.0003826113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002269322,"about_ca_topic_score_gemma":0.003534894,"domain_scores_codex":[0.9985268,0.0005362569,0.0001106513,0.0004885885,0.000224085,0.0001134649],"domain_scores_gemma":[0.9975751,0.001273383,0.000475989,0.0003611845,0.0001705845,0.0001437492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004379616,0.00004924381,0.9242872,0.000167451,0.001975963,0.0007482136,0.001674249,0.002311974,0.0333944,0.00224904,0.0001100766,0.03259415],"study_design_scores_gemma":[0.000007668612,0.00008327579,0.9945379,0.00001337529,0.0001384668,0.0003917441,0.0002524214,0.00175784,0.0008887076,0.001362936,0.0005473245,0.00001818859],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996126,0.0006778401,0.002069508,0.0000723016,0.000007085094,0.000008208732,0.00008498607,0.00001941874,0.0009346209],"genre_scores_gemma":[0.9990189,0.0002323989,0.0004553805,0.00002251496,0.00000764179,0.000005095629,0.00009244515,0.000007451722,0.0001581463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002269322,"threshold_uncertainty_score":0.01047379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01264971306803495,"score_gpt":0.2748473039685911,"score_spread":0.2621975909005562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}