{"id":"W4324136253","doi":"10.1136/gutjnl-2022-328332","title":"Comprehensive molecular phenotyping of<i>ARID1A</i>-deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities","year":2023,"lang":"en","type":"article","venue":"Gut","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Medical Research Council; Cancer Science Institute of Singapore, National University of Singapore; Duke-NUS Medical School","keywords":"ARID1A; Cancer research; Epigenetics; Biology; Epigenomics; Chromatin; Enhancer; Bromodomain; Cancer; Genetics; Gene; DNA methylation; Transcription factor; Gene expression; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001419949,0.0001631243,0.0002088273,0.0002744434,0.0001145566,0.0002518105,0.0001399972,0.0001415895,0.000926711],"category_scores_gemma":[0.0001264356,0.0001292212,0.000235502,0.0002446691,0.0001637077,0.0001054878,0.0001957254,0.0002031113,0.0002828157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001642399,"about_ca_system_score_gemma":0.0001259351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005432547,"about_ca_topic_score_gemma":0.0009966566,"domain_scores_codex":[0.9999334,0.000007024826,0.00000615727,0.00002457786,0.00001622416,0.00001268008],"domain_scores_gemma":[0.999928,0.00001013771,0.0000241568,0.00001097828,0.000009300973,0.00001738181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002440276,0.00001067806,0.02405867,0.00005868807,0.00002614301,0.000144192,0.00005453271,0.0002409545,0.9700079,0.00006083599,0.0001078987,0.004985509],"study_design_scores_gemma":[0.00003250727,0.0006639137,0.5106987,0.00001845781,0.000170296,0.004180996,0.000422623,0.003799224,0.471586,0.0003014558,0.008107663,0.00001804422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958588,0.0005677758,0.001476531,0.00004004248,0.000003160838,0.0000184441,0.001475099,0.00005509775,0.000504997],"genre_scores_gemma":[0.9951687,0.0005373438,0.001532897,0.0000408999,0.000003029348,0.00002896939,0.001962258,0.00001810643,0.0007077435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000926711,"threshold_uncertainty_score":0.003100157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05465569501769361,"score_gpt":0.2999164491358341,"score_spread":0.2452607541181405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}