{"id":"W4324136609","doi":"10.1200/jco.2023.41.6_suppl.506","title":"A pilot study of tazemetostat and pembrolizumab in advanced urothelial carcinoma (ETCTN 10183).","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Institutes of Health","keywords":"Medicine; Pembrolizumab; Internal medicine; Oncology; Cohort; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002294907,0.0008977186,0.001720794,0.0003793185,0.0005681858,0.000668943,0.0009478163,0.001175793,0.005262694],"category_scores_gemma":[0.001113412,0.0005529188,0.001400014,0.0004944925,0.0008640841,0.0009187695,0.0005184346,0.00243381,0.001165095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001100496,"about_ca_system_score_gemma":0.002216792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001977972,"about_ca_topic_score_gemma":0.003661382,"domain_scores_codex":[0.9991288,0.0004618386,0.00005172576,0.000133967,0.00006778479,0.0001559612],"domain_scores_gemma":[0.9984273,0.0002882544,0.0001954167,0.0001872706,0.00009893911,0.0008028799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5679526,0.2937489,0.01231035,0.0007297048,0.0009068203,0.00100432,0.0006259445,0.001697435,0.04992752,0.0002129,0.001754848,0.06912864],"study_design_scores_gemma":[0.07484597,0.9088573,0.01283907,0.00001364626,0.0001710876,0.0002348398,0.00005650147,0.0002911853,0.001584461,0.00003902074,0.001056138,0.0000106324],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959468,0.0003706547,0.0001479753,0.0001268937,0.00004394794,0.001846272,0.0005255325,0.00002270405,0.0009691021],"genre_scores_gemma":[0.993323,0.0005325387,0.0009003443,0.0003784485,0.0001333518,0.002218816,0.001041364,0.0000121091,0.001460027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005262694,"threshold_uncertainty_score":0.01760548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1625085955871581,"score_gpt":0.4724198347077909,"score_spread":0.3099112391206328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}