{"id":"W4324136676","doi":"10.1200/jco.2023.41.6_suppl.148","title":"Dosing, safety, and pharmacokinetics (PK) of combination therapy with darolutamide (DARO), androgen-deprivation therapy (ADT), and docetaxel (DOC) in patients with metastatic hormone-sensitive prostate cancer (mHSPC) in the ARASENS study.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Medicine; Dosing; Pharmacokinetics; Discontinuation; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003319035,0.0008092719,0.00183569,0.0003446581,0.0001640873,0.0006750433,0.0005574799,0.0006079531,0.001454336],"category_scores_gemma":[0.002783139,0.0004999021,0.002149048,0.0006096721,0.0006075771,0.0006789477,0.0004133726,0.00137917,0.0002607755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008895764,"about_ca_system_score_gemma":0.0009615889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005845911,"about_ca_topic_score_gemma":0.001680358,"domain_scores_codex":[0.9980088,0.001340419,0.0001174646,0.0002092709,0.0002237403,0.0001003831],"domain_scores_gemma":[0.9983644,0.000411161,0.0006990841,0.0001763459,0.00007375798,0.0002752676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8312327,0.007288032,0.06235777,0.0007607852,0.008419397,0.0001356697,0.0002537599,0.003978885,0.009364914,0.0001422952,0.001848263,0.07421742],"study_design_scores_gemma":[0.366973,0.4006766,0.208465,0.0001261648,0.007407554,0.0006854911,0.0001445849,0.00603233,0.003039915,0.0004929893,0.005846052,0.0001103562],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99628,0.002097176,0.0002121836,0.0001114147,0.0000213155,0.000193705,0.0006070065,0.00001661954,0.00046054],"genre_scores_gemma":[0.9974152,0.0007628376,0.0004646089,0.00009175658,0.00003830575,0.0001812642,0.0007687096,0.000006266042,0.0002710133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003319035,"threshold_uncertainty_score":0.01755297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0895156565479519,"score_gpt":0.4494159933776046,"score_spread":0.3599003368296527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}