{"id":"W4324136707","doi":"10.1200/jco.2023.41.6_suppl.646","title":"Real-world outcomes in patients with metastatic renal cell carcinoma (mRCC) receiving dual immune checkpoint inhibitor (ICI-ICI) regimens or immune checkpoint inhibitor and tyrosine kinase inhibitor (ICI-TKI) combinations as first-line therapy: A British Columbia (BC) population-based analysis.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"","keywords":"Medicine; Sunitinib; Nivolumab; Ipilimumab; Renal cell carcinoma; Internal medicine; Pembrolizumab; Axitinib; Oncology; Population; Tyrosine-kinase inhibitor; Proportional hazards model; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006781058,0.0002503156,0.0004421354,0.001464071,0.0006353804,0.001018548,0.0006347897,0.0006338717,0.001864807],"category_scores_gemma":[0.002800504,0.0002898081,0.00051295,0.003519212,0.0004653616,0.0005047432,0.0008460444,0.0009664638,0.0003864655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00276493,"about_ca_system_score_gemma":0.001655906,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.3004296,"about_ca_topic_score_gemma":0.3058458,"domain_scores_codex":[0.9992685,0.0001128871,0.0001080763,0.000167792,0.0001947611,0.0001480568],"domain_scores_gemma":[0.9972304,0.0003155613,0.001351891,0.0001717108,0.0003974832,0.0005329063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001759061,0.00004122482,0.9983535,0.00002040273,0.00005995363,0.00006088168,0.00008246723,0.00006796799,0.00004757545,0.00001061994,0.0003663751,0.0007131633],"study_design_scores_gemma":[0.00001760668,0.00006504096,0.9987602,0.00001554877,0.00003035528,0.0001560894,0.0002800654,0.0002378802,0.00002256639,0.00001353863,0.0003934266,0.000007820924],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931317,0.000307645,0.00003584101,0.00007636908,0.000003829934,0.00002981657,0.005922336,0.000004548775,0.0004880452],"genre_scores_gemma":[0.9945043,0.0001885352,0.00006913145,0.00005705834,0.000007512766,0.00003050739,0.004966156,0.000002835652,0.0001739958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6995704,"threshold_uncertainty_score":0.5973618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05497399050232772,"score_gpt":0.3487207684273048,"score_spread":0.2937467779249771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}