{"id":"W4324136951","doi":"10.1200/jco.2023.41.6_suppl.lba442","title":"Pembrolizumab (pembro) monotherapy for patients (pts) with high-risk non–muscle-invasive bladder cancer (HR NMIBC) unresponsive to bacillus Calmette–Guérin (BCG): Results from cohort B of the phase 2 KEYNOTE-057 trial.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Cohort; Bladder cancer; Cystectomy; Pembrolizumab; Internal medicine; Oncology; Cancer; Metastasis; Urology; Surgery; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009451637,0.0005505993,0.0008162281,0.000206233,0.0003120051,0.0005891672,0.00034697,0.0005884233,0.002883762],"category_scores_gemma":[0.0005097832,0.0003081059,0.0008343939,0.0003153266,0.0002596395,0.0005769185,0.0003169127,0.001364005,0.0006103329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006792801,"about_ca_system_score_gemma":0.00092329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008954774,"about_ca_topic_score_gemma":0.002942298,"domain_scores_codex":[0.9998043,0.00008740529,0.00001420624,0.00003296407,0.00001940436,0.00004167438],"domain_scores_gemma":[0.999715,0.00003665581,0.00008181595,0.00001937758,0.00002118665,0.0001257757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7107983,0.02867151,0.05406252,0.002096274,0.003571313,0.0005473797,0.0003639028,0.001755707,0.03508475,0.0002556698,0.01384854,0.1489442],"study_design_scores_gemma":[0.4737715,0.3611205,0.1406961,0.0002766945,0.002475202,0.001051879,0.0002191685,0.001476133,0.003977812,0.0003636984,0.01452321,0.0000480476],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908267,0.003283095,0.0002453968,0.0003410639,0.00005833418,0.001391441,0.002091856,0.00003333527,0.001728691],"genre_scores_gemma":[0.9875457,0.002576654,0.0007259696,0.0009559614,0.0001062663,0.001833044,0.004513904,0.00001265926,0.001729771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002883762,"threshold_uncertainty_score":0.009647131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07345774090978048,"score_gpt":0.4316168756357661,"score_spread":0.3581591347259856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}