{"id":"W4324136969","doi":"10.1200/jco.2023.41.6_suppl.tps396","title":"DASL-HiCaP: A randomized, phase 3, double-blind trial of darolutamide with androgen-deprivation therapy and definitive or salvage radiation for localized very high-risk prostate cancer.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University; Ottawa Hospital; Centre Hospitalier Universitaire de Sherbrooke; Sunnybrook Health Science Centre; Health Sciences Centre; McGill University; Jewish General Hospital","funders":"Australian and New Zealand Urogenital and Prostate Cancer Trials Group; Cancer Australia","keywords":"Medicine; Prostate cancer; Androgen deprivation therapy; Clinical endpoint; Docetaxel; Placebo; Internal medicine; Salvage therapy; Randomization; Prostatectomy; Oncology; Randomized controlled trial; Antiandrogen; Urology; Surgery; Cancer; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002770557,0.002694882,0.003414612,0.0007524667,0.0006892968,0.001478084,0.001715614,0.002287784,0.009611613],"category_scores_gemma":[0.002065583,0.001092531,0.001771627,0.0007115466,0.002141756,0.00131635,0.0006005647,0.004162807,0.001841939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009705682,"about_ca_system_score_gemma":0.003055547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001408249,"about_ca_topic_score_gemma":0.002997301,"domain_scores_codex":[0.999052,0.0005676085,0.00004042829,0.0001340478,0.00005898049,0.0001470509],"domain_scores_gemma":[0.9987495,0.0002919774,0.0002247889,0.00008626375,0.00007623066,0.0005713234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9803021,0.00840337,0.0001878302,0.0005400965,0.0004528975,0.00001920197,0.00003125712,0.0002304937,0.001635161,0.0001305784,0.001006584,0.007060385],"study_design_scores_gemma":[0.9680073,0.0308417,0.0002831648,0.00001354469,0.0001053287,0.00001366192,0.000008794272,0.0001695678,0.0001664089,0.00006261373,0.000319388,0.000008521863],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9622158,0.007651644,0.001422732,0.001184415,0.001542484,0.01619493,0.00337313,0.0006933312,0.005721568],"genre_scores_gemma":[0.9571887,0.004470877,0.003446434,0.002843529,0.0008894859,0.02013136,0.00294589,0.00008069196,0.008003187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009611613,"threshold_uncertainty_score":0.03215402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2047591432241928,"score_gpt":0.5064863245693975,"score_spread":0.3017271813452047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}