{"id":"W4324137009","doi":"10.1200/jco.2023.41.6_suppl.tps274","title":"PROMISE Registry: A prostate cancer registry of outcomes and germline mutations for improved survival and treatment effectiveness.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; CHEK2; Prostate cancer; MSH2; PALB2; MSH6; Genetic testing; Oncology; PTEN; Germline; MLH1; Internal medicine; Cancer; Germline mutation; Genetics; DNA mismatch repair; Mutation; Gene; Colorectal cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006008261,0.0005313164,0.0009317451,0.003558114,0.0006081826,0.001752013,0.002015353,0.0006460287,0.03018082],"category_scores_gemma":[0.01798084,0.000465061,0.0006814143,0.007854131,0.0002568935,0.002660633,0.003110975,0.001143403,0.0113974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001604255,"about_ca_system_score_gemma":0.006546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009642527,"about_ca_topic_score_gemma":0.01157479,"domain_scores_codex":[0.9971868,0.0007842246,0.0005064906,0.0004427771,0.0008614263,0.0002182064],"domain_scores_gemma":[0.9740215,0.004439786,0.008731346,0.00304612,0.006104106,0.003657122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.00181838,0.0002349728,0.1436014,0.0008913684,0.0002241457,0.0001091164,0.0001454803,0.0008487857,0.0002416678,0.003225067,0.7405624,0.1080971],"study_design_scores_gemma":[0.002100001,0.001188369,0.5107033,0.001226924,0.0006129117,0.001005559,0.0006097544,0.004705321,0.001136207,0.003795425,0.4727173,0.0001988984],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"empirical","genre_scores_codex":[0.02933072,0.001837383,0.003380726,0.005564469,0.0002046512,0.0015603,0.9084609,0.003306147,0.0463547],"genre_scores_gemma":[0.1379743,0.002070397,0.01005239,0.002309854,0.0003987549,0.003909399,0.8291779,0.0009158108,0.01319113],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03018082,"threshold_uncertainty_score":0.1009649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1641488013438777,"score_gpt":0.5276381257444269,"score_spread":0.3634893244005493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}