{"id":"W4324138171","doi":"10.3233/jad-221184","title":"Regulation of USP25 by SP1 Associates with Amyloidogenesis","year":2023,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Sp1 transcription factor; Chromosome 21; Pathogenesis; Biology; Transcription factor; Gene expression; Molecular biology; Transcription (linguistics); Cell biology; Gene; Promoter; Genetics; Chromosome; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001882964,0.0005435826,0.0002634824,0.0004075469,0.0002205069,0.0002931257,0.0001833627,0.0003082026,0.001214561],"category_scores_gemma":[0.0001706222,0.0001623152,0.0004841872,0.0002015653,0.0003322227,0.0001440987,0.0002377146,0.0004790451,0.0003999545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002967038,"about_ca_system_score_gemma":0.0001194215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002659959,"about_ca_topic_score_gemma":0.0002290741,"domain_scores_codex":[0.9998394,0.00002628874,0.00001621544,0.00004804236,0.00003807098,0.00003203969],"domain_scores_gemma":[0.999716,0.00004145511,0.0001158233,0.0000186257,0.00003866312,0.00006941981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000221256,0.00004247146,0.003044287,0.00008341887,0.00001731275,0.0003719291,0.00003524485,0.00005957199,0.9940042,0.0001105338,0.0001855461,0.001824226],"study_design_scores_gemma":[0.00006251552,0.0004666329,0.09152407,0.00003774419,0.0001139702,0.002718,0.0001127797,0.002044203,0.8984638,0.0005242694,0.003910257,0.00002170975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910254,0.005169716,0.002400019,0.0001374069,0.00002945298,0.00001880642,0.0003979758,0.00007316329,0.0007481058],"genre_scores_gemma":[0.9951004,0.001817409,0.00138126,0.00005233338,0.00002635461,0.00003242179,0.0007256682,0.00001391345,0.0008503009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001214561,"threshold_uncertainty_score":0.004063129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01539871056893471,"score_gpt":0.2485940251261108,"score_spread":0.2331953145571761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}