{"id":"W4324140055","doi":"10.1161/circ.147.suppl_1.p619","title":"Abstract P619: DNA Methylation at <i>SREBF1</i> and Long-Term Changes in Body Composition: The POUNDS Lost Trial","year":2023,"lang":"en","type":"article","venue":"Circulation","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Medicine; dNaM; Obesity; Overweight; Endocrinology; Internal medicine; Weight loss; Body mass index; Fat mass; Animal science; DNA methylation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001431123,0.0007595092,0.00165931,0.0001845192,0.0004425961,0.0008781512,0.0004759718,0.001343767,0.004571156],"category_scores_gemma":[0.001192575,0.000288544,0.001348412,0.0003015381,0.000564407,0.0006286668,0.0003540395,0.002157962,0.0006211749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003078264,"about_ca_system_score_gemma":0.0004291594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009420382,"about_ca_topic_score_gemma":0.0008442855,"domain_scores_codex":[0.9995378,0.0002229701,0.00003678117,0.0001057877,0.00004799655,0.00004862863],"domain_scores_gemma":[0.9994608,0.0001277791,0.0001523514,0.00005335837,0.00004577802,0.0001599908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9508846,0.003121774,0.01240497,0.001197248,0.003428716,0.00009233179,0.00006949717,0.0003345668,0.004706255,0.0001306966,0.001946397,0.02168294],"study_design_scores_gemma":[0.7853402,0.1220739,0.07819579,0.000359467,0.006398885,0.0001821143,0.0001021531,0.001054325,0.001696839,0.0007893832,0.003763844,0.0000430088],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883145,0.005846638,0.0005233685,0.001289373,0.0003816767,0.0006605412,0.001410464,0.00006425357,0.00150915],"genre_scores_gemma":[0.9915467,0.001403025,0.0005044058,0.00119267,0.0003154045,0.001037549,0.001169254,0.00001568953,0.00281541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004571156,"threshold_uncertainty_score":0.01529211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02440489438892439,"score_gpt":0.2867160025588856,"score_spread":0.2623111081699612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}