{"id":"W4324140201","doi":"10.1161/circ.147.suppl_1.p339","title":"Abstract P339: The Clinical Application and Ancestral Diversity of Cardiometabolic Polygenic Risk Scores","year":2023,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiovascular Health and Risk Factors","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of British Columbia","funders":"","keywords":"Medicine; Genome-wide association study; Disease; MEDLINE; Population; Dyslipidemia; Single-nucleotide polymorphism; Internal medicine; Genetics; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03720784,0.001318959,0.004947493,0.01320443,0.0006687731,0.004739143,0.001717928,0.002047549,0.008177407],"category_scores_gemma":[0.1590135,0.0006595574,0.007086245,0.01462325,0.00141219,0.003576532,0.002191233,0.001879529,0.0007924284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002499527,"about_ca_system_score_gemma":0.007201744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003474557,"about_ca_topic_score_gemma":0.005712027,"domain_scores_codex":[0.9654921,0.01594694,0.0111632,0.001983599,0.005094592,0.0003194367],"domain_scores_gemma":[0.8030164,0.165455,0.01776051,0.0026037,0.0106512,0.0005132542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"observational","study_design_scores_codex":[0.0006307445,0.00002320958,0.008457827,0.8098933,0.02730942,0.0002404442,0.0004866174,0.0004572498,0.0003087945,0.003597235,0.01030409,0.1382911],"study_design_scores_gemma":[0.0006216006,0.0002796396,0.02436311,0.8072172,0.09293258,0.0008220024,0.000578312,0.001018424,0.0004109011,0.01281162,0.05882233,0.0001223801],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.003080917,0.9755195,0.004962255,0.005768549,0.0008123078,0.001970201,0.005266543,0.00005849519,0.002561311],"genre_scores_gemma":[0.1078243,0.8515021,0.0223112,0.00479985,0.002088232,0.006158664,0.004264892,0.00006525306,0.0009854558],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03720784,"threshold_uncertainty_score":0.1967762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05109779727908141,"score_gpt":0.3431649054835845,"score_spread":0.2920671082045031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}