{"id":"W4324141674","doi":"10.1016/j.joca.2023.01.552","title":"Development Of A Novel Synovial Joint-On-A-Chip To Model The Complex Osteoarthritic Knee Microenvironment","year":2023,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Orthopaedic implants and arthroplasty","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Osteoarthritis; Joint (building); Chip; Knee Joint; Medicine; Computer science; Engineering; Pathology; Surgery; Telecommunications; Civil engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003239518,0.0004062461,0.0004334149,0.0002246786,0.0002412448,0.000518557,0.0006423673,0.0006212078,0.0007124378],"category_scores_gemma":[0.0002430344,0.0002825276,0.0004216257,0.00016586,0.0002345993,0.0002988928,0.0003848181,0.0005477949,0.0003443686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002415677,"about_ca_system_score_gemma":0.0005537313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001500954,"about_ca_topic_score_gemma":0.003505152,"domain_scores_codex":[0.9997632,0.00002716045,0.00001459026,0.00005240849,0.0001001252,0.00004253619],"domain_scores_gemma":[0.9998202,0.00004825012,0.00002743721,0.00002306053,0.00004448699,0.00003665988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003888139,0.00007396525,0.0004256069,0.000136666,0.00001810884,0.00007269681,0.00003078952,0.002825548,0.9912174,0.0004294953,0.0002758335,0.004455127],"study_design_scores_gemma":[0.00005435308,0.0007122247,0.003450149,0.00002472658,0.0001013687,0.0003337436,0.00009896474,0.08488857,0.8938913,0.0003733661,0.01600801,0.00006328876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6235194,0.003394629,0.3618813,0.0003336858,0.0008482251,0.0005460409,0.001530889,0.001199158,0.00674663],"genre_scores_gemma":[0.7888507,0.001370401,0.2044401,0.0002649044,0.00005201234,0.0007127157,0.000763513,0.00006779556,0.003477874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001500954,"threshold_uncertainty_score":0.002984464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03749693022685115,"score_gpt":0.2519255786616801,"score_spread":0.214428648434829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}