{"id":"W4324145221","doi":"10.3389/fnins.2023.1107436","title":"Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer’s disease","year":2023,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health","keywords":"Ergothioneine; Disease; Antioxidant; Amyloid (mycology); Amyloid beta; Chemistry; Biology; Medicine; Biochemistry; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002683129,0.000831207,0.000650265,0.000950192,0.0002345395,0.0003880247,0.0003768559,0.000664707,0.001494763],"category_scores_gemma":[0.0001078538,0.0002175457,0.0004931707,0.0002501491,0.0003780891,0.0005165836,0.0001880078,0.0009825105,0.0003499041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003535243,"about_ca_system_score_gemma":0.0003084454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001377748,"about_ca_topic_score_gemma":0.002375956,"domain_scores_codex":[0.9997472,0.00003073064,0.00003717663,0.00006275965,0.0000609915,0.0000610914],"domain_scores_gemma":[0.9998149,0.000009535063,0.00006527645,0.00001766505,0.00003350273,0.00005911573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00151834,0.0002634334,0.0002344849,0.0001094993,0.00001939904,0.00007409393,0.00003831839,0.00003578195,0.9955038,0.00003665055,0.0001076187,0.002058561],"study_design_scores_gemma":[0.0002384209,0.005630823,0.01200472,0.00004348908,0.0001682632,0.0005268187,0.0001538426,0.0006011099,0.9768319,0.0001162518,0.00366168,0.00002286348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992918,0.002954886,0.001356,0.0002515859,0.000100969,0.0000672756,0.0008073897,0.000256584,0.001287306],"genre_scores_gemma":[0.9849679,0.002500309,0.002566637,0.0001727143,0.00003060263,0.0001795191,0.0009484785,0.0000567413,0.008577064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001494763,"threshold_uncertainty_score":0.005000472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04353429788488777,"score_gpt":0.3048615019220235,"score_spread":0.2613272040371358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}