{"id":"W4324148925","doi":"10.3390/cancers15061743","title":"Addressing Natural Killer Cell Dysfunction and Plasticity in Cell-Based Cancer Therapeutics","year":2023,"lang":"en","type":"review","venue":"Cancers","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxic T cell; Biology; Immune system; Innate lymphoid cell; Tumor microenvironment; Cancer immunotherapy; Lymphokine-activated killer cell; Immunology; Immunotherapy; Cancer research; Cancer; Natural killer cell; Cell; Interleukin 12; Interleukin 21; Acquired immune system; T cell; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003908066,0.0006685854,0.001010664,0.001434194,0.0002060379,0.0007795677,0.0006581295,0.0009078169,0.003175081],"category_scores_gemma":[0.0003774785,0.0001975075,0.0003391238,0.001237796,0.0003591404,0.0009991261,0.0006622634,0.001689751,0.001998544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005259492,"about_ca_system_score_gemma":0.0006526943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004363417,"about_ca_topic_score_gemma":0.0009696152,"domain_scores_codex":[0.9998646,0.00002526506,0.00001482878,0.00002004624,0.00005956256,0.00001567914],"domain_scores_gemma":[0.9998776,0.00005538291,0.00001545571,0.000004589633,0.00003079215,0.0000161557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006978527,0.00008697963,0.0001051883,0.012496,0.00005416988,0.0001811968,0.00005753413,0.0004705848,0.004215639,0.00589821,0.02294772,0.953417],"study_design_scores_gemma":[0.00001670517,0.0001073043,0.0004509939,0.001907569,0.00005175098,0.0009641972,0.00003642501,0.0001040569,0.0006902987,0.002019357,0.9936394,0.00001185946],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001885763,0.9974512,0.0002308743,0.0002379619,0.0002731772,0.000006854861,0.00001478498,0.00001178153,0.001584771],"genre_scores_gemma":[0.0008790719,0.9975628,0.0002094023,0.0001819171,0.0001529597,0.000009805071,0.00002716409,0.000001904981,0.0009750457],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003175081,"threshold_uncertainty_score":0.01062173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07999150090635036,"score_gpt":0.3344024308017194,"score_spread":0.2544109298953691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}