{"id":"W4324149258","doi":"10.3390/cells12060886","title":"The Pleiotropic Ubiquitin-Specific Peptidase 16 and Its Many Substrates","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Defense","keywords":"Deubiquitinating enzyme; Ubiquitin; Cell biology; Mitosis; Biology; Cytoplasm; Carcinogenesis; Histone; Cell cycle; Cell; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003608113,0.0008482715,0.001010862,0.002075796,0.0002610541,0.0009146437,0.0007099528,0.0007776105,0.004350149],"category_scores_gemma":[0.0004116671,0.0002658255,0.0003763257,0.002061382,0.0003522186,0.0009892357,0.000647668,0.001531112,0.003433604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000603182,"about_ca_system_score_gemma":0.0007349331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007205242,"about_ca_topic_score_gemma":0.001349645,"domain_scores_codex":[0.9998792,0.0000148619,0.0000148802,0.00002119098,0.00005486163,0.00001495442],"domain_scores_gemma":[0.9998555,0.00004400981,0.00002556788,0.000006136695,0.00004196611,0.00002676069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009004102,0.00006485035,0.0001300916,0.009094434,0.00006361192,0.0002346144,0.00003327971,0.0003017831,0.002938869,0.003132267,0.03794328,0.9459729],"study_design_scores_gemma":[0.000009368747,0.00003662828,0.0003564776,0.0009307015,0.00002737425,0.0008659498,0.00001418033,0.00003039187,0.0004218671,0.0009376187,0.9963612,0.000008353183],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001356195,0.9978536,0.0001187358,0.0001861478,0.0001816465,0.000003905003,0.00002484552,0.00001089231,0.001484596],"genre_scores_gemma":[0.0006035295,0.997598,0.0001664803,0.0001390773,0.0001180397,0.000005374377,0.00006584909,0.000002061918,0.001301651],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004350149,"threshold_uncertainty_score":0.01455271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05377753274166535,"score_gpt":0.2950635210361292,"score_spread":0.2412859882944638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}