{"id":"W4324302758","doi":"10.1021/acschemneuro.2c00676","title":"Development of a Novel Electrochemiluminescence ELISA for Quantification of α-Synuclein Phosphorylated at Ser<sup>129</sup> in Biological Samples","year":2023,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; University of California, Irvine; National Institutes of Health; Multiple System Atrophy Coalition; National Center for Research Resources; CurePSP; National Institute on Aging; Alzheimer's Association; Weston Brain Institute; Michael J. Fox Foundation for Parkinson's Research; Arizona Department of Health Services; Parkinson Alliance; Arizona Biomedical Research Commission; U.S. Department of Energy","keywords":"Synucleinopathies; Dementia with Lewy bodies; Immunoassay; Electrochemiluminescence; Biomarker; Cerebrospinal fluid; Molecular biology; Antibody; Biology; Western blot; Chemistry; Alpha-synuclein; Parkinson's disease; Biochemistry; Pathology; Medicine; Dementia; Detection limit; Disease; Neuroscience; Immunology; Chromatography; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001923882,0.00014982,0.0003013185,0.00009938083,0.00004933851,0.000005046977,0.0002027004,0.00008792609,0.000005835605],"category_scores_gemma":[0.000646663,0.000123038,0.00006535937,0.0008277033,0.0001611749,0.00004627581,0.0001082708,0.00006961772,0.000004092715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007877836,"about_ca_system_score_gemma":0.0001430315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007093899,"about_ca_topic_score_gemma":0.000001661391,"domain_scores_codex":[0.9984604,0.000009067221,0.0004126446,0.0005025094,0.0002823223,0.0003330614],"domain_scores_gemma":[0.9993256,0.0001188781,0.0001298898,0.000224999,0.00008627643,0.000114325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002422238,0.0005190867,0.0114097,0.00006275789,0.000005200991,0.000003465529,0.0001139683,0.00001308245,0.987026,0.00009082638,0.00002754277,0.0004861573],"study_design_scores_gemma":[0.001154921,0.00008821557,0.05046378,0.00006514175,0.00001305103,0.000005167692,0.00003153599,0.004802861,0.9427838,0.00002991916,0.0004631794,0.00009848011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986902,0.0000319604,0.0006524439,0.00009702569,0.00002559216,0.0004093083,0.0000348825,0.00004638059,0.0000121475],"genre_scores_gemma":[0.9947019,0.00004452429,0.004936105,0.0000968591,0.000007208255,0.00007134788,0.00009112247,0.00001169328,0.00003928548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04424224,"threshold_uncertainty_score":0.5017345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08496773486462628,"score_gpt":0.307242506471134,"score_spread":0.2222747716065077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}