{"id":"W4324303386","doi":"10.1007/s10620-023-07822-7","title":"Ustekinumab Trough Concentrations Are Associated with Biochemical Outcomes in Patients with Crohn’s Disease","year":2023,"lang":"en","type":"article","venue":"Digestive Diseases and Sciences","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Celgene; Teva Pharmaceutical Industries; Pfizer","keywords":"Medicine; Internal medicine; Gastroenterology; Prospective cohort study; Crohn's disease; Quartile; Population; Faecal calprotectin; Hepatology; Inflammatory bowel disease; Calprotectin; Surgery; Confidence interval; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005855638,0.0001615465,0.0001309209,0.00006010332,0.0002019147,0.00007260984,0.0001295777,0.00003670536,0.000005671332],"category_scores_gemma":[0.0002896549,0.0001111516,0.00003829513,0.0002836252,0.0005825293,0.00002246392,0.00005778682,0.0000401709,0.000002803395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001840758,"about_ca_system_score_gemma":0.0001860154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005790687,"about_ca_topic_score_gemma":0.00001687292,"domain_scores_codex":[0.9988381,0.00005098816,0.0001213461,0.0004191218,0.0002702959,0.0003000997],"domain_scores_gemma":[0.9994177,0.0000342284,0.00007902095,0.0001338619,0.0001012908,0.0002339646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003401842,0.0001789986,0.9988801,0.000007940505,0.00002587756,0.00008588729,0.00003102269,0.000187879,0.0000242149,0.00006991176,0.0001405185,0.00002749078],"study_design_scores_gemma":[0.001152188,0.0001168793,0.9980481,0.00005154495,0.00003584517,1.102497e-7,0.0002020605,0.0001206911,0.00002033098,0.00003603676,0.00001648604,0.000199765],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998908,0.0000794162,0.000005576203,0.0001206066,0.00002844702,0.000295527,0.0004794764,0.00002707166,0.00005583951],"genre_scores_gemma":[0.9993726,0.00001151314,0.00001015946,0.0001343847,0.00001632835,0.00005587229,0.0003114729,0.00001014683,0.00007750355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008320124,"threshold_uncertainty_score":0.4532631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008815192496051519,"score_gpt":0.2386294241904031,"score_spread":0.2298142316943516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}