{"id":"W4324308738","doi":"10.15252/embj.2023113490","title":"Uptake‐independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates","year":2023,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Stavros Niarchos Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Secretion; Extracellular; Biology; Phagocytosis; Microbiology; Intracellular; Cytosol; Macrophage; Mycobacterium tuberculosis; Programmed cell death; Virulence; Cell biology; Intracellular parasite; Tuberculosis; Biochemistry; Apoptosis; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002362071,0.0001762367,0.0004598992,0.0001853379,0.0002345843,0.00003714383,0.0002860437,0.0001028061,0.0008789945],"category_scores_gemma":[0.000560008,0.0001049275,0.0002750361,0.0003669875,0.0001657585,0.00008907649,0.00010151,0.0008049055,0.0002614582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006446826,"about_ca_system_score_gemma":0.00008395247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004490707,"about_ca_topic_score_gemma":0.000002959739,"domain_scores_codex":[0.9976991,0.0003102709,0.0005988997,0.0001981619,0.000541467,0.0006521461],"domain_scores_gemma":[0.9985939,0.0003702794,0.0002110263,0.000334751,0.0001689345,0.0003210745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005558632,0.0002320219,0.0244296,0.0002026053,0.001076472,0.0008728955,0.000981871,0.0002193911,0.7906759,0.0001663619,0.1549404,0.02564659],"study_design_scores_gemma":[0.008799003,0.002735302,0.2881683,0.001750625,0.00124874,0.01721408,0.006489659,0.01455246,0.3322931,0.006938048,0.3185202,0.001290544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704096,0.01181669,0.0001181153,0.01649493,0.0003457813,0.0001739499,0.00001920252,0.00004929918,0.0005723923],"genre_scores_gemma":[0.9806247,0.01489326,0.0001554952,0.0003333137,0.000537341,0.000009153041,0.00002516833,0.00003575932,0.003385767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4583828,"threshold_uncertainty_score":0.9624373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02607395288322302,"score_gpt":0.3079274406157378,"score_spread":0.2818534877325148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}