{"id":"W4324309758","doi":"10.1084/jem.20212383","title":"Overexpression of <i>Lmo2</i> initiates T-lymphoblastic leukemia via impaired thymocyte competition","year":2023,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; Cancer Council Victoria; Australian Research Council; Medical Research Council; National Health and Medical Research Council; Servier; State Government of Victoria; Australian Government; AstraZeneca; Children's Medical Research","keywords":"Biology; Thymocyte; Transcription factor; Transgene; Leukemia; Cell biology; Cancer research; Suppressor; Stem cell; Genetically modified mouse; T cell; T-cell leukemia; Immunology; Genetics; Gene; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009463943,0.0002550373,0.0001721745,0.0001426488,0.0001415932,0.000367633,0.0001893311,0.0002208379,0.001091926],"category_scores_gemma":[0.00008215832,0.0001301365,0.000144272,0.000131805,0.0002939639,0.0001726521,0.0002169131,0.0004983252,0.0003543041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003415123,"about_ca_system_score_gemma":0.000207455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00057762,"about_ca_topic_score_gemma":0.0009519826,"domain_scores_codex":[0.9998525,0.00001919976,0.00001372118,0.00002961116,0.00004065881,0.00004429934],"domain_scores_gemma":[0.9998735,0.00002176841,0.00004445238,0.00001319608,0.000005599585,0.00004140719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003978879,0.00001082386,0.0001122634,0.000007306886,0.000001606387,0.00004139578,0.000007161732,0.00003231208,0.9993396,0.0001726519,0.00001710748,0.0002180424],"study_design_scores_gemma":[0.00001002546,0.0000612422,0.001118384,0.00000154787,0.000005406536,0.0001862187,0.00001533104,0.0006154496,0.9961576,0.00004028948,0.001786424,0.000002177676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951152,0.0003601564,0.002621899,0.00008264369,0.00002172411,0.00001620386,0.0002714611,0.0001519656,0.001358899],"genre_scores_gemma":[0.9968065,0.0002050929,0.001083928,0.00003033467,0.000005967705,0.00001683565,0.000281928,0.00004085302,0.001528614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001091926,"threshold_uncertainty_score":0.003652871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01064292850570511,"score_gpt":0.2670607360785147,"score_spread":0.2564178075728096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}