{"id":"W4324309909","doi":"10.1002/alz.13014","title":"Blood‐brain barrier integrity impacts the use of plasma amyloid‐β as a proxy of brain amyloid‐β pathology","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Cerebrospinal fluid and hydrocephalus","field":"Neuroscience","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; Instituto de Salud Carlos III; Instituto Nacional de Ciência e Tecnologia para Excitotoxicidade e Neuroproteção; Parkinsonfonden; European Commission; Familjen Erling-Perssons Stiftelse; Hjärnfonden; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; UK Dementia Research Institute; Vetenskapsrådet; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Demensförbundet; International Society for Neurochemistry; BrightFocus Foundation; Gun och Bertil Stohnes Stiftelse; Consortium canadien en neurodégénérescence associée au vieillissement; Canadian Institutes of Health Research; National Institute on Aging; Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona; Alzheimerfonden; Weston Brain Institute; Alzheimer's Drug Discovery Foundation","keywords":"Blood–brain barrier; Cerebrospinal fluid; Positron emission tomography; Blood plasma; Albumin; Medicine; Pathology; Neuroimaging; Evans Blue; Internal medicine; Psychology; Chemistry; Neuroscience; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003863575,0.0007145072,0.0004966152,0.0005342109,0.0004314563,0.001659513,0.0005370378,0.0005505019,0.002215484],"category_scores_gemma":[0.01513351,0.0003148807,0.0008116613,0.0006180509,0.0006088684,0.0007781405,0.0006727884,0.0005974569,0.0003011132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003791839,"about_ca_system_score_gemma":0.0006104021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00448716,"about_ca_topic_score_gemma":0.003781236,"domain_scores_codex":[0.998255,0.0009228285,0.0001069054,0.0004242595,0.0002037722,0.00008736594],"domain_scores_gemma":[0.991809,0.003523385,0.002912947,0.0008346847,0.0006016666,0.0003184089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000976276,0.0001103346,0.9825248,0.0001267145,0.00166448,0.0001298555,0.0003561295,0.0005414254,0.002247663,0.0003207999,0.000345668,0.0106559],"study_design_scores_gemma":[0.00001961621,0.0004738452,0.9919935,0.0000659161,0.0007241757,0.0005828553,0.0002291204,0.002358766,0.001525332,0.001217589,0.0007932168,0.00001590934],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939765,0.001646094,0.002254348,0.0002305888,0.00003254773,0.00002348635,0.0004914492,0.0000300425,0.001314861],"genre_scores_gemma":[0.9989104,0.0001539107,0.0005827734,0.00003460082,0.000006861263,0.00001180279,0.0001039157,0.000007139158,0.0001885121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00448716,"threshold_uncertainty_score":0.02043277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05854843147391567,"score_gpt":0.2979104052262249,"score_spread":0.2393619737523092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}