{"id":"W4324309909","doi":"10.1002/alz.13014","title":"Blood‐brain barrier integrity impacts the use of plasma amyloid‐β as a proxy of brain amyloid‐β pathology","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Cerebrospinal fluid and hydrocephalus","field":"Neuroscience","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; Instituto de Salud Carlos III; Instituto Nacional de Ciência e Tecnologia para Excitotoxicidade e Neuroproteção; Parkinsonfonden; European Commission; Familjen Erling-Perssons Stiftelse; Hjärnfonden; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; UK Dementia Research Institute; Vetenskapsrådet; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Demensförbundet; International Society for Neurochemistry; BrightFocus Foundation; Gun och Bertil Stohnes Stiftelse; Consortium canadien en neurodégénérescence associée au vieillissement; Canadian Institutes of Health Research; National Institute on Aging; Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona; Alzheimerfonden; Weston Brain Institute; Alzheimer's Drug Discovery Foundation","keywords":"Blood–brain barrier; Cerebrospinal fluid; Positron emission tomography; Blood plasma; Albumin; Medicine; Pathology; Neuroimaging; Evans Blue; Internal medicine; Psychology; Chemistry; Neuroscience; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007074233,0.0003163283,0.0004370574,0.0002280716,0.0002123308,0.00006745587,0.0007068891,0.0001648216,0.0004269628],"category_scores_gemma":[0.001956752,0.0002365264,0.0002418045,0.0009670192,0.0005865004,0.0003259684,0.0004410012,0.0004275028,0.000240047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005302238,"about_ca_system_score_gemma":0.0001726437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000408584,"about_ca_topic_score_gemma":0.0001008526,"domain_scores_codex":[0.9970301,0.0004304154,0.0006843471,0.0006205752,0.00057214,0.0006624599],"domain_scores_gemma":[0.9976364,0.001021634,0.0003194812,0.0007464304,0.0001015394,0.0001745134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001487712,0.0002394248,0.00436063,0.00002355371,0.001021771,0.00009665759,0.001417375,0.00004195133,0.9713222,0.004667208,0.01303941,0.003621007],"study_design_scores_gemma":[0.001019349,0.0006983971,0.01129329,0.00004452962,0.002198666,0.0001166214,0.000113593,0.001303552,0.9642357,0.001038216,0.01761516,0.0003229581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940711,0.001277541,0.00001535268,0.002798997,0.0003990978,0.0006405048,0.0001191718,0.0001210724,0.0005571753],"genre_scores_gemma":[0.9970778,0.0001076457,0.000147489,0.002301101,0.00007361871,0.00004577732,0.00001392234,0.0000472733,0.0001854308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007086568,"threshold_uncertainty_score":0.9645265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05854843147391567,"score_gpt":0.2979104052262249,"score_spread":0.2393619737523092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}