{"id":"W4324311114","doi":"10.1182/bloodadvances.2022008345","title":"The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma","year":2023,"lang":"en","type":"article","venue":"Blood Advances","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont; McGill University Health Centre; Jewish General Hospital; University of Ottawa; McGill University","funders":"National Cancer Institute; National Institutes of Health; Emory University; Terry Fox Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; McGill University; Jewish General Hospital; Canadian Institutes of Health Research; Leukemia and Lymphoma Society","keywords":"Carfilzomib; Proteasome; Bortezomib; Multiple myeloma; Pharmacology; Proteasome inhibitor; Cancer research; Biology; Medicine; Cell biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002272167,0.0001714857,0.0002803381,0.0001158539,0.000280052,0.00003028065,0.0002305127,0.00004824932,0.00001917227],"category_scores_gemma":[0.001055011,0.00008641188,0.0001330837,0.0006489774,0.000325171,0.0001003025,0.0001123363,0.0001987423,0.00003986862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002220239,"about_ca_system_score_gemma":0.00008414343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001622515,"about_ca_topic_score_gemma":0.0003192137,"domain_scores_codex":[0.9982399,0.0001234209,0.0003590684,0.0002701144,0.0005209874,0.0004864577],"domain_scores_gemma":[0.9984619,0.0008191688,0.0001143194,0.0003996715,0.00009049962,0.0001144421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002875657,0.001054805,0.7115827,0.0002508548,0.000645173,0.0003732034,0.00117294,0.0002397677,0.166247,0.0002273208,0.0009289157,0.1144017],"study_design_scores_gemma":[0.01173744,0.0004163562,0.8959161,0.0001944423,0.00008476351,0.00001447226,0.0007826619,0.0006056386,0.06983122,0.0005023738,0.01975812,0.0001563742],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942981,0.001911837,0.000002547667,0.001414285,0.0002431608,0.001762448,0.00004976055,0.00006997929,0.0002478709],"genre_scores_gemma":[0.9980066,0.0006376317,0.0002804585,0.00002410682,0.0002572657,0.0002536224,0.00005309411,0.00002371653,0.0004635276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1843334,"threshold_uncertainty_score":0.3523774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02877557707826679,"score_gpt":0.3057353426982065,"score_spread":0.2769597656199397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}