{"id":"W4324325394","doi":"10.1126/scitranslmed.abn2110","title":"A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis","year":2023,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Pancreatitis Pathology and Treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Stanford Diabetes Research Center; National Institute of Diabetes and Digestive and Kidney Diseases; Servier; National Institutes of Health; Jazz Pharmaceuticals","keywords":"Medicine; Pancreatitis; Asparaginase; Adverse effect; Vitamin; Acute pancreatitis; Adverse Event Reporting System; Retinyl palmitate; Concomitant; Internal medicine; Pharmacology; Drug; Cohort; Retinol; Gastroenterology; Leukemia; Lymphoblastic Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001725387,0.0001476519,0.0003963274,0.0005916812,0.000158218,0.000009621212,0.0001241478,0.00006362289,0.00002575539],"category_scores_gemma":[0.0003879426,0.0001133694,0.00004351304,0.001985611,0.0003748727,0.00009206386,0.000009076982,0.0001082432,0.00004118756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001181245,"about_ca_system_score_gemma":0.0002708315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001667409,"about_ca_topic_score_gemma":0.00003423875,"domain_scores_codex":[0.9981319,0.0000592355,0.0003265973,0.0004390322,0.0006068729,0.0004363839],"domain_scores_gemma":[0.9991522,0.0002411556,0.00005271775,0.0001965931,0.00016582,0.0001914965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001138899,0.0008330473,0.8734652,0.0002837342,0.0002265535,0.0004025537,0.0118979,0.001698425,0.04117026,0.05631232,0.001209787,0.0113613],"study_design_scores_gemma":[0.004711264,0.0008050272,0.9733267,0.0004150375,0.000109185,0.0001360978,0.0005381772,0.01612917,0.0002378264,0.003056355,0.0003849181,0.0001502059],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.961909,0.0008048735,0.003482786,0.01556544,0.0003691127,0.003226823,0.00008234203,0.0001971618,0.01436246],"genre_scores_gemma":[0.9966447,0.00002357342,0.001223594,0.000516694,0.00009912893,0.0006764888,0.0001861766,0.00001364904,0.0006159791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0998615,"threshold_uncertainty_score":0.4623069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04031832778798688,"score_gpt":0.3276069593070323,"score_spread":0.2872886315190454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}