{"id":"W4324344163","doi":"10.1038/s41586-023-05790-6","title":"Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Cilag; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; Rega Foundation; National Institute of Allergy and Infectious Diseases; Vlaamse regering; Servier; KU Leuven; National Institutes of Health; U.S. Department of Health and Human Services; Fonds Wetenschappelijk Onderzoek; Agentschap Innoveren en Ondernemen; Wellcome Trust; U.S. Department of Defense","keywords":"Dengue virus; Dengue fever; Virology; Serotype; NS3; Antibody-dependent enhancement; In vivo; Virus; Dengue vaccine; Viral replication; Biology; Hepatitis C virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001177013,0.0001229819,0.0002000306,0.0002058902,0.00005798986,0.00002954909,0.00007378429,0.0004605145,0.0001250952],"category_scores_gemma":[0.0001088278,0.0001064748,0.00008508018,0.0003839947,0.00001213647,0.00008685583,0.00004442385,0.001258277,0.000110546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006886906,"about_ca_system_score_gemma":0.0000328949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007976715,"about_ca_topic_score_gemma":0.000178524,"domain_scores_codex":[0.9991122,0.00001821163,0.0001774129,0.0002414718,0.0002156265,0.0002350825],"domain_scores_gemma":[0.9995689,0.00004057435,0.00005418175,0.000191502,0.0000614863,0.00008338845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008063565,0.0007554296,0.1405027,0.001037929,0.0002460349,0.001364552,0.001633464,0.0001620245,0.7393619,0.001689999,0.06014661,0.05229298],"study_design_scores_gemma":[0.005849838,0.0002371305,0.8972224,0.001290491,0.0002360325,0.0000527464,0.001128858,0.005894269,0.0572503,0.0005326674,0.02982591,0.0004793333],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995019,0.0007961591,0.000001840168,0.001245864,0.0003234317,0.0002877806,0.00001024849,0.0001253694,0.002190369],"genre_scores_gemma":[0.9974003,0.00004675117,0.00001474395,0.001352398,0.0004035554,0.00003248374,0.0001060706,0.00002315521,0.0006205392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7567198,"threshold_uncertainty_score":0.5466655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008504802336763737,"score_gpt":0.335156427443868,"score_spread":0.3266516251071043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}