{"id":"W4324344163","doi":"10.1038/s41586-023-05790-6","title":"Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Cilag; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; Rega Foundation; National Institute of Allergy and Infectious Diseases; Vlaamse regering; Servier; KU Leuven; National Institutes of Health; U.S. Department of Health and Human Services; Fonds Wetenschappelijk Onderzoek; Agentschap Innoveren en Ondernemen; Wellcome Trust; U.S. Department of Defense","keywords":"Dengue virus; Dengue fever; Virology; Serotype; NS3; Antibody-dependent enhancement; In vivo; Virus; Dengue vaccine; Viral replication; Biology; Hepatitis C virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002439991,0.000514681,0.0002627393,0.0002689484,0.0002712343,0.0002375787,0.0003430152,0.0002039733,0.003700978],"category_scores_gemma":[0.0001047231,0.0001715066,0.0002064475,0.0001339161,0.0002213704,0.0001247458,0.0001414234,0.0006057463,0.000958827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003216907,"about_ca_system_score_gemma":0.000336443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001441826,"about_ca_topic_score_gemma":0.002778862,"domain_scores_codex":[0.9998916,0.0000312324,0.000004984836,0.00001829193,0.00003267551,0.00002119678],"domain_scores_gemma":[0.999953,0.00001043177,0.000008435907,0.000006185943,0.000007229438,0.00001459764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006923763,0.0004738112,0.0002236908,0.0001587757,0.0000265688,0.00007258965,0.00004325685,0.0002237478,0.9905268,0.0004334952,0.001112858,0.006012032],"study_design_scores_gemma":[0.0002442898,0.0050373,0.002675336,0.00002295003,0.00004199834,0.0003868982,0.00003915001,0.002630061,0.9617369,0.0002410537,0.02693485,0.000009205965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9504951,0.01828044,0.008693208,0.0004934755,0.0003546833,0.000381725,0.001577149,0.0004348602,0.01928936],"genre_scores_gemma":[0.96966,0.006705667,0.005746746,0.0002318081,0.00007993444,0.0002866518,0.001899866,0.0000552797,0.01533403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003700978,"threshold_uncertainty_score":0.01238096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008504802336763737,"score_gpt":0.335156427443868,"score_spread":0.3266516251071043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}