{"id":"W4324344227","doi":"10.1038/s41586-023-05801-6","title":"The dietary sweetener sucralose is a negative modulator of T cell-mediated responses","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Biochemical Analysis and Sensing Techniques","field":"Nursing","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"Engineering and Physical Sciences Research Council; Medical Research Council; Deutsche Forschungsgemeinschaft; Wellcome Trust; Francis Crick Institute; Home Office; Cancer Research UK","keywords":"Sucralose; T cell; Intracellular; Autoimmunity; Cell; CD8; Immune system; Cell biology; Chemistry; Biology; Immunology; Food science; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001210983,0.0004135336,0.0001907588,0.0002031746,0.00007537159,0.000258993,0.0001442212,0.0002290627,0.00156614],"category_scores_gemma":[0.0001203967,0.00008317356,0.000187532,0.000137108,0.0001580911,0.0001563862,0.0001640194,0.0003798825,0.0003781673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001195213,"about_ca_system_score_gemma":0.000087915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001050845,"about_ca_topic_score_gemma":0.0001514427,"domain_scores_codex":[0.999895,0.00002524071,0.000008607502,0.00002001976,0.00003592344,0.00001526206],"domain_scores_gemma":[0.9999046,0.00001595839,0.00003383864,0.000008364252,0.00001249373,0.00002464447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001182847,0.00001023105,0.00007122803,0.0000440195,0.000003229509,0.000024076,0.000002534863,0.00001608574,0.9978769,0.00004438392,0.00002849095,0.001760548],"study_design_scores_gemma":[0.00002080618,0.0005717804,0.003582544,0.00001816052,0.00001575763,0.0002331267,0.00001566566,0.0003186197,0.9912848,0.00008181269,0.003853152,0.000003857663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9627146,0.02291534,0.007825642,0.0003870947,0.0001482397,0.00004774489,0.0005374803,0.0002249356,0.005198866],"genre_scores_gemma":[0.9883591,0.005117339,0.003703926,0.0001699552,0.00004689757,0.0000385957,0.0002722884,0.00002028328,0.002271586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00156614,"threshold_uncertainty_score":0.005239248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0130515316554689,"score_gpt":0.2771397885558666,"score_spread":0.2640882569003977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}