{"id":"W4324344258","doi":"10.1038/s41586-023-05798-y","title":"Structural basis of odorant recognition by a human odorant receptor","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Olfactory and Sensory Function Studies","field":"Neuroscience","cited_by":227,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; UK Research and Innovation; National Institute on Deafness and Other Communication Disorders; Medical Research Council; University of California, San Francisco; Canadian Institutes of Health Research; National Science Foundation; Vallee Foundation; Deutsche Forschungsgemeinschaft; National Institutes of Health; Edward Mallinckrodt, Jr. Foundation; Sandler Foundation","keywords":"Receptor; Propionate; Olfaction; Chemistry; Biophysics; Biochemistry; Molecular recognition; Olfactory receptor; Biology; Cell biology; Molecule; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001011795,0.0001187091,0.0001695866,0.0001010306,0.000250493,0.0000166644,0.0001111249,0.0003515379,0.0004755393],"category_scores_gemma":[0.0003964045,0.00009523171,0.00007914891,0.0005063338,0.00008761651,0.0001221398,0.00003736828,0.0007472551,0.000199259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001686146,"about_ca_system_score_gemma":0.000007786432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004805375,"about_ca_topic_score_gemma":0.000004348221,"domain_scores_codex":[0.9989667,0.0001027341,0.0001758378,0.0002883855,0.0002849127,0.0001814562],"domain_scores_gemma":[0.9995191,0.0001383997,0.00009188611,0.0001433863,0.00006691164,0.00004033689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005484152,0.00001353064,0.0003340326,0.00002721695,0.000007983045,0.000004253947,0.0003633386,0.000002142743,0.9342622,0.0001159434,0.06231745,0.002497126],"study_design_scores_gemma":[0.0004645548,0.0001137683,0.004305644,0.00002769754,0.00001551247,0.000004847292,0.0003965508,0.00004262066,0.9595225,0.0006426401,0.03426933,0.0001943371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964894,0.00008181242,0.000001244284,0.0006589871,0.0009497578,0.0001254739,0.0003606798,0.000166956,0.001165672],"genre_scores_gemma":[0.9972272,0.00004453763,0.0000162987,0.0005749697,0.00009856703,0.000005900112,0.00005032976,0.00001309885,0.001969079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02804812,"threshold_uncertainty_score":0.5206822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1257107935960839,"score_gpt":0.3001357064472717,"score_spread":0.1744249128511877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}