{"id":"W4324344303","doi":"10.1021/acsmedchemlett.3c00008","title":"Cyclic Peptidic Furin Inhibitors Developed by Combinatorial Chemistry","year":2023,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Narodowe Centrum Nauki; Université de Sherbrooke","keywords":"Furin; Proteases; Serine protease; Trypsin; Peptide; Serine; Chemistry; Protease inhibitor (pharmacology); Biochemistry; Protease; In vitro; Cyclic peptide; Computational biology; Biology; Enzyme; Human immunodeficiency virus (HIV); Virology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001677012,0.0006124405,0.000386769,0.0003923063,0.0001528292,0.0003945145,0.0004235915,0.0002850447,0.001401213],"category_scores_gemma":[0.0001986093,0.0002012976,0.0002606033,0.0004294792,0.0001700186,0.0002281296,0.0002812773,0.0005657506,0.0006073878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004588261,"about_ca_system_score_gemma":0.0002331683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003876845,"about_ca_topic_score_gemma":0.0006902299,"domain_scores_codex":[0.9997947,0.00002115736,0.00001401816,0.00005088823,0.00006741659,0.00005176078],"domain_scores_gemma":[0.999935,0.000006852624,0.00002086307,0.000007096306,0.00001217269,0.00001805512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000227866,0.000121914,0.0001367797,0.0001377851,0.00003202169,0.000117328,0.00002383996,0.0030682,0.9802725,0.0009600171,0.0005291873,0.01437255],"study_design_scores_gemma":[0.00006938764,0.0006951587,0.0004344172,0.000006560933,0.00002749368,0.0001797005,0.000005217241,0.005063002,0.9879841,0.0000918852,0.00542516,0.0000180454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9202075,0.004435329,0.05809041,0.0001964307,0.0001545296,0.0006961199,0.001317219,0.0007407657,0.01416157],"genre_scores_gemma":[0.9613886,0.00203009,0.03074883,0.0001375419,0.00002801941,0.0003856469,0.0009691639,0.00006393926,0.00424814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001401213,"threshold_uncertainty_score":0.004687548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00707988088812876,"score_gpt":0.2170451376541605,"score_spread":0.2099652567660318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}