{"id":"W4324344303","doi":"10.1021/acsmedchemlett.3c00008","title":"Cyclic Peptidic Furin Inhibitors Developed by Combinatorial Chemistry","year":2023,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Narodowe Centrum Nauki; Université de Sherbrooke","keywords":"Furin; Proteases; Serine protease; Trypsin; Peptide; Serine; Chemistry; Protease inhibitor (pharmacology); Biochemistry; Protease; In vitro; Cyclic peptide; Computational biology; Biology; Enzyme; Human immunodeficiency virus (HIV); Virology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002758817,0.0003149266,0.0002410959,0.00002286164,0.0001285149,0.00002308803,0.0003343731,0.0003120045,0.0001093187],"category_scores_gemma":[0.00008246592,0.000330987,0.0001268323,0.0002687528,0.0001663114,0.000007098276,0.00008259032,0.0002960747,0.00004556487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004465176,"about_ca_system_score_gemma":0.00008876258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002155663,"about_ca_topic_score_gemma":9.505178e-7,"domain_scores_codex":[0.9980969,0.00002287486,0.0003642181,0.0005757568,0.0004342312,0.0005060642],"domain_scores_gemma":[0.9991844,0.00002067418,0.0001145169,0.0004015046,0.00005097333,0.0002278877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008052442,0.00003370669,0.001842745,0.0001278978,0.00005394077,0.00006056472,0.00006824502,0.000004506076,0.9666623,9.460636e-7,0.030919,0.0001455732],"study_design_scores_gemma":[0.001122703,0.00002275396,0.0004147032,0.00003505785,0.000034686,0.00003175742,0.0001388276,0.000005590735,0.8941486,0.0000122605,0.1036864,0.0003466255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960192,0.0002782628,0.000227909,0.001754303,0.0004717535,0.0001196602,0.00002809976,0.0001027241,0.0009980364],"genre_scores_gemma":[0.9834212,0.0002015866,0.00001736229,0.0005067425,0.001600586,0.00003504053,0.01283251,0.00005340666,0.00133158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07276738,"threshold_uncertainty_score":0.9999142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00707988088812876,"score_gpt":0.2170451376541605,"score_spread":0.2099652567660318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}