{"id":"W4324355452","doi":"10.3390/neuroglia4010006","title":"Targeting Bioinformatics Predicted Biomarkers Associated with Cell Proliferation and Migration for Treating Gliomas: Preclinical Studies in a GL261 Mouse Model","year":2023,"lang":"en","type":"article","venue":"Neuroglia","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Prince Edward Island","funders":"Girton College, University of Cambridge; National Institutes of Health","keywords":"Immunohistochemistry; Glioma; Cancer research; Antibody; Biomarker; Medicine; Cell; Cell growth; In silico; Biology; Pathology; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006830957,0.001084888,0.0007117833,0.0006322984,0.000166936,0.0004474852,0.0003038154,0.0004663219,0.001225982],"category_scores_gemma":[0.0003149963,0.0002317856,0.0005834909,0.0003128543,0.0002540801,0.0002572141,0.0001917349,0.0009072722,0.0005255879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004986438,"about_ca_system_score_gemma":0.0004752376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00091579,"about_ca_topic_score_gemma":0.001430606,"domain_scores_codex":[0.9997024,0.00004228478,0.00001919928,0.00006628544,0.00012884,0.00004103802],"domain_scores_gemma":[0.9997405,0.00004694052,0.0001043532,0.00001913125,0.000050334,0.00003872813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006858259,0.0003183424,0.001697993,0.0003256531,0.00008560182,0.00007788844,0.00002449536,0.005123595,0.9830635,0.0002223444,0.0005553113,0.007819518],"study_design_scores_gemma":[0.0001068955,0.001819671,0.004714353,0.00002408198,0.000212837,0.000243157,0.00002587562,0.02728513,0.9594177,0.0002246689,0.005902123,0.00002341943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9320437,0.004102101,0.05269847,0.0005296045,0.0001505875,0.0003469069,0.005770376,0.00211569,0.00224265],"genre_scores_gemma":[0.9129397,0.003786966,0.07008509,0.0003147718,0.00002977082,0.0006356134,0.008028178,0.0003071204,0.003872731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001225982,"threshold_uncertainty_score":0.004101276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05656279512952619,"score_gpt":0.3270592327245467,"score_spread":0.2704964375950206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}