{"id":"W4324368797","doi":"10.1016/j.bbadis.2023.166688","title":"Platelet activation and ferroptosis mediated NETosis drives heme induced pulmonary thrombosis","year":2023,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Department of Science and Technology, Ministry of Science and Technology, India","keywords":"Platelet activation; Neutrophil extracellular traps; Heme; Platelet; Immunology; Medicine; Inflammation; Chemistry; Cell biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001759632,0.0001579285,0.0002125478,0.0002000108,0.0002189885,0.0005126914,0.0002005573,0.0005924298,0.002105554],"category_scores_gemma":[0.0002555195,0.0001817101,0.0001549042,0.00009981498,0.000292793,0.0002484103,0.0002905938,0.0006585747,0.0004757339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002926661,"about_ca_system_score_gemma":0.0001664378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000228219,"about_ca_topic_score_gemma":0.0003721985,"domain_scores_codex":[0.9998057,0.00004245815,0.0000148503,0.0000348903,0.00004050087,0.00006154896],"domain_scores_gemma":[0.9998488,0.00003239715,0.00004078756,0.0000204649,0.00001186229,0.00004559576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009509557,0.0001588135,0.003877712,0.00005873406,0.000008015122,0.001621738,0.00008326786,0.00009251866,0.9893191,0.001351519,0.0002908311,0.002186757],"study_design_scores_gemma":[0.0002087933,0.001818441,0.1167767,0.00004822159,0.00006176712,0.01590026,0.0007350885,0.007229378,0.8474939,0.003062235,0.00664322,0.00002196518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960654,0.0005352484,0.00130381,0.0002275342,0.00003448947,0.00003769642,0.0001159956,0.00003267662,0.001647187],"genre_scores_gemma":[0.9984793,0.00016629,0.0002949179,0.00003846676,0.0000191935,0.00001796492,0.00007735437,0.000002853311,0.0009036191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002105554,"threshold_uncertainty_score":0.007043839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01861032223498343,"score_gpt":0.2539484629834953,"score_spread":0.2353381407485119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}