{"id":"W4324370648","doi":"10.31083/j.fbl2803048","title":"Investigating Endocrine Disrupting Impacts of Nine Disinfection Byproducts on Human and Zebrafish Estrogen Receptor Alpha","year":2023,"lang":"en","type":"article","venue":"Frontiers in Bioscience-Landmark","topic":"Water Treatment and Disinfection","field":"Environmental Science","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Universiteit Antwerpen","keywords":"Estrogen receptor; Chemistry; Estrogen; Estrogen receptor alpha; Endocrine system; Receptor; Reporter gene; Internal medicine; Pharmacology; Endocrinology; Hormone; Biochemistry; Biology; Gene expression; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002384089,0.0004198704,0.0001915041,0.0002775122,0.0001149085,0.0001300098,0.0001209919,0.0002124751,0.0007744982],"category_scores_gemma":[0.0001664978,0.0001148703,0.0004371569,0.0001466672,0.0001580177,0.0001139449,0.0001778414,0.0002539948,0.0001238924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004092018,"about_ca_system_score_gemma":0.0003511293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002943076,"about_ca_topic_score_gemma":0.005282363,"domain_scores_codex":[0.9998572,0.00001619776,0.00001068591,0.00003392214,0.00005840859,0.00002348902],"domain_scores_gemma":[0.9999022,0.00001210842,0.00003309554,0.000006561543,0.00003681997,0.000009068038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009467066,0.00001561818,0.001165738,0.00007788413,0.00001305204,0.00002920942,0.00001236193,0.0001318871,0.9967997,0.00001570488,0.00002761953,0.001616453],"study_design_scores_gemma":[0.000005343031,0.0008932385,0.008071273,0.000007365195,0.00004991267,0.0001018208,0.00004761302,0.0002729076,0.9892207,0.00001635115,0.001308189,0.000005368826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947243,0.001949016,0.001903191,0.00005233406,0.00001533557,0.00004032179,0.00048625,0.00002284174,0.000806445],"genre_scores_gemma":[0.9911453,0.002666548,0.003251413,0.00008469907,0.000005189555,0.00004489273,0.0005933976,0.00001235053,0.002196089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002943076,"threshold_uncertainty_score":0.005851865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01641431878377991,"score_gpt":0.2622796702688103,"score_spread":0.2458653514850304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}