{"id":"W4327547459","doi":"10.1371/journal.pgen.1010680","title":"Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells","year":2023,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Fonds de Recherche du Québec - Santé; Compute Canada; Canadian Institutes of Health Research; Institut de Cardiologie de Montréal; National Institutes of Health; Fondation Institut de Cardiologie de Montréal; Deutsche Forschungsgemeinschaft; Canada Foundation for Innovation; Bundesministerium für Bildung und Forschung; National Human Genome Research Institute; Canada Excellence Research Chairs, Government of Canada; Heart and Stroke Foundation of Canada","keywords":"CRISPR; Biology; Genome-wide association study; Coronary artery disease; Genetics; Disease; Computational biology; Single-nucleotide polymorphism; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008754248,0.000526715,0.0006826828,0.0005492828,0.0003408273,0.0005980531,0.0003610117,0.0006417839,0.002626143],"category_scores_gemma":[0.001056997,0.0002330498,0.0005214151,0.0004025259,0.0003990474,0.0001303163,0.0005354499,0.0008008425,0.0004108143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003872693,"about_ca_system_score_gemma":0.0003352389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008467113,"about_ca_topic_score_gemma":0.002807457,"domain_scores_codex":[0.9991915,0.0001312796,0.00008512729,0.0003052374,0.000179985,0.000106925],"domain_scores_gemma":[0.9992362,0.000345816,0.0001493476,0.0001294214,0.0000607299,0.00007841598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002980697,0.0000548476,0.004263676,0.0001295434,0.000139703,0.0003411889,0.00006095232,0.00154109,0.9843106,0.000426332,0.0002150828,0.008218878],"study_design_scores_gemma":[0.0001242597,0.001270157,0.06007593,0.00005382859,0.0005947113,0.00249252,0.000105682,0.01320971,0.9120856,0.0009392857,0.008962082,0.00008620377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9523627,0.001103155,0.03840014,0.000202344,0.000119224,0.0001557646,0.003985696,0.00108173,0.002589295],"genre_scores_gemma":[0.981243,0.000306951,0.01531605,0.0002413103,0.0000133776,0.000121658,0.001457671,0.0001275784,0.001172427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002626143,"threshold_uncertainty_score":0.008785367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01259432315196034,"score_gpt":0.2296872246424265,"score_spread":0.2170929014904661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}