{"id":"W4327547459","doi":"10.1371/journal.pgen.1010680","title":"Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells","year":2023,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Fonds de Recherche du Québec - Santé; Compute Canada; Canadian Institutes of Health Research; Institut de Cardiologie de Montréal; National Institutes of Health; Fondation Institut de Cardiologie de Montréal; Deutsche Forschungsgemeinschaft; Canada Foundation for Innovation; Bundesministerium für Bildung und Forschung; National Human Genome Research Institute; Canada Excellence Research Chairs, Government of Canada; Heart and Stroke Foundation of Canada","keywords":"CRISPR; Biology; Genome-wide association study; Coronary artery disease; Genetics; Disease; Computational biology; Single-nucleotide polymorphism; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005897286,0.00013126,0.0001300394,0.00007762228,0.00003979685,0.00001054845,0.0001175064,0.0000842796,0.00003357674],"category_scores_gemma":[0.000108881,0.0001249466,0.00008352794,0.0001832454,0.00008233252,0.000003042541,0.00005400582,0.00004811393,0.00001570813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000149247,"about_ca_system_score_gemma":0.000133064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002683943,"about_ca_topic_score_gemma":0.00002422887,"domain_scores_codex":[0.9990607,0.00007063081,0.0002006427,0.0002459082,0.0002196084,0.0002025358],"domain_scores_gemma":[0.9993582,0.00002715968,0.00006861189,0.0002993969,0.00009964638,0.0001470009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000269899,0.0007034864,0.2436074,0.0000503305,0.0002004151,0.00004953169,0.0001607572,0.03200644,0.7216358,0.0000190207,0.00106151,0.0002353594],"study_design_scores_gemma":[0.002975268,0.0002810296,0.786454,0.00004831215,0.0001614941,8.568234e-7,0.0001130533,0.05912575,0.1493188,0.0001054194,0.001008303,0.0004077428],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988769,0.0002575595,0.0001237825,0.00006778457,0.0000430506,0.0002550517,0.0002552811,0.00002304756,0.00009757798],"genre_scores_gemma":[0.9984692,0.0001287669,0.0001089061,0.000101544,0.00005855332,0.00003073127,0.000672513,0.00002813845,0.0004015837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.572317,"threshold_uncertainty_score":0.5095175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01259432315196034,"score_gpt":0.2296872246424265,"score_spread":0.2170929014904661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}