{"id":"W4327556923","doi":"10.1038/s41467-023-37129-0","title":"Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Parasitic Infections and Diagnostics","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; University of California, San Diego; University of North Carolina at Chapel Hill; National Institutes of Health; National Institute of Allergy and Infectious Diseases; McMaster University; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Cryptosporidium parvum; Interferon; Cryptosporidium; Biology; Antiparasitic; Virology; Microbiology; Interferon type I; RNA silencing; Diarrhea; Immunology; RNA; Medicine; RNA interference; Feces; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001066369,0.0003717838,0.000147095,0.0001250552,0.0001353423,0.0002196124,0.0001867729,0.000339557,0.001549957],"category_scores_gemma":[0.00005231644,0.00009470306,0.0002022441,0.00007284753,0.0002184602,0.0001585033,0.0001381484,0.000720277,0.0003414062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002800261,"about_ca_system_score_gemma":0.0002270427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006530682,"about_ca_topic_score_gemma":0.0005681647,"domain_scores_codex":[0.9999061,0.00001196029,0.000005300833,0.000018776,0.00002718743,0.0000307564],"domain_scores_gemma":[0.99992,0.00001249922,0.00002162056,0.000008383299,0.000008952284,0.00002856677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000707297,0.0000163602,0.0001667628,0.00002664175,0.000001817628,0.00002307433,0.000003191126,0.00003658332,0.9988652,0.00008794129,0.00005016027,0.0006514481],"study_design_scores_gemma":[0.0000136431,0.0002414249,0.002815763,0.000006659309,0.000006145272,0.0002097476,0.00001946524,0.0004962952,0.9942904,0.00005843514,0.001839833,0.000002308804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925553,0.001244696,0.002659958,0.0002900687,0.00006194327,0.0000290828,0.0007456203,0.0001146053,0.002298753],"genre_scores_gemma":[0.9940603,0.0005646028,0.001739381,0.0001289184,0.00001104525,0.00002153388,0.000596119,0.00001736456,0.002860627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001549957,"threshold_uncertainty_score":0.005185127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02857351994457197,"score_gpt":0.3300841865838242,"score_spread":0.3015106666392522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}