{"id":"W4327558030","doi":"10.1016/j.ymthe.2023.03.001","title":"Two gene therapies for hemophilia available: Now what?","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Hemophilia Society","funders":"","keywords":"Medicine; Food and drug administration; Gene transfer; Genetic enhancement; Internal medicine; Coagulopathy; Scopus; Gene; MEDLINE; Pharmacology; Biology; Political science; Genetics; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00402023,0.0007267385,0.002307305,0.001262942,0.0009622978,0.005157879,0.0007457297,0.005439144,0.0235403],"category_scores_gemma":[0.00538093,0.0003484125,0.001181752,0.00105746,0.003275666,0.008049913,0.001400983,0.007912762,0.004089066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001758797,"about_ca_system_score_gemma":0.00312986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001478973,"about_ca_topic_score_gemma":0.00382074,"domain_scores_codex":[0.9984189,0.0004605054,0.0001334038,0.0001885885,0.0005192209,0.0002793586],"domain_scores_gemma":[0.9955238,0.001827969,0.0006848692,0.000185994,0.0007414508,0.001035839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004283115,0.0008459068,0.003520473,0.002685281,0.000217572,0.001082863,0.000446058,0.000268507,0.008415422,0.03163516,0.1344573,0.8121424],"study_design_scores_gemma":[0.001081427,0.00223682,0.005573678,0.00365365,0.0005415861,0.003137337,0.001649,0.0002709251,0.00431126,0.02251017,0.9548799,0.0001541003],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.006021983,0.74214,0.002101356,0.2280467,0.007876247,0.0000603862,0.0002213802,0.0001524375,0.01337937],"genre_scores_gemma":[0.09804907,0.723025,0.008997203,0.1184494,0.01648768,0.0003194958,0.000501861,0.0001909964,0.03397933],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.0235403,"threshold_uncertainty_score":0.07875013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0485482312897219,"score_gpt":0.3406363242263605,"score_spread":0.2920880929366386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}