{"id":"W4327558030","doi":"10.1016/j.ymthe.2023.03.001","title":"Two gene therapies for hemophilia available: Now what?","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Hemophilia Society","funders":"","keywords":"Medicine; Food and drug administration; Gene transfer; Genetic enhancement; Internal medicine; Coagulopathy; Scopus; Gene; MEDLINE; Pharmacology; Biology; Political science; Genetics; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003103122,0.0002016263,0.0002848865,0.0001917206,0.0001305699,0.00008505531,0.0001370196,0.00009120908,0.000511932],"category_scores_gemma":[0.00002239072,0.0001476828,0.0002155135,0.0004858127,0.0000786719,0.00009728736,0.00002781502,0.0001177031,0.001350125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004376601,"about_ca_system_score_gemma":0.0001076619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007162716,"about_ca_topic_score_gemma":0.000001575887,"domain_scores_codex":[0.9985592,0.00004940949,0.0001731025,0.0003607108,0.0003678981,0.0004896288],"domain_scores_gemma":[0.9991313,0.00007296157,0.00002929155,0.0004823816,0.0001351403,0.0001489314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006399621,0.0002346642,0.001555165,0.00004994714,0.000596931,0.0004257289,0.0003523479,0.000006826325,0.892274,0.0002915949,0.01051461,0.09305822],"study_design_scores_gemma":[0.008994879,0.001042195,0.001192259,0.00008015827,0.00004606713,0.0000389085,0.0001815826,0.0005479779,0.7611901,0.002076279,0.2243212,0.0002883474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9700335,0.01286987,0.0002239345,0.01346266,0.0002721205,0.001507803,0.00001221007,0.0002853957,0.001332449],"genre_scores_gemma":[0.8270089,0.04870129,0.004838488,0.005806993,0.0008191929,0.001104045,0.0007143123,0.0003074019,0.1106994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2138066,"threshold_uncertainty_score":0.9994274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0485482312897219,"score_gpt":0.3406363242263605,"score_spread":0.2920880929366386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}