{"id":"W4327569474","doi":"10.1016/j.dcn.2023.101232","title":"A biologically informed polygenic score of neuronal plasticity moderates the association between cognitive aptitudes and cortical thickness in adolescents","year":2023,"lang":"en","type":"article","venue":"Developmental Cognitive Neuroscience","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McGill University; Université du Québec à Chicoutimi; Hospital for Sick Children; Montreal Neurological Institute and Hospital; SickKids Foundation; University of Toronto; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Fédération pour la Recherche sur le Cerveau; National Institute for Health and Care Research; Fondation de France; Bundesministerium für Bildung und Forschung; Fondation pour la Recherche Médicale; National Natural Science Foundation of China; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; King's College London; Deutsche Forschungsgemeinschaft; National Institute on Drug Abuse; Mission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives; Science Foundation Ireland; European Commission","keywords":"Neuroplasticity; Psychology; Association (psychology); Cognition; Cortex (anatomy); Single-nucleotide polymorphism; Genome-wide association study; Intelligence quotient; Cerebral cortex; Neuroscience; Developmental psychology; Gene; Biology; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006803462,0.0003792683,0.0002960801,0.0005042727,0.000317425,0.0005574737,0.0002614552,0.0003983306,0.00155048],"category_scores_gemma":[0.001531715,0.0002941994,0.0005943131,0.0005171465,0.0003897922,0.0002330089,0.0003933923,0.0005090112,0.00008287959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002117795,"about_ca_system_score_gemma":0.0002556508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01094086,"about_ca_topic_score_gemma":0.01343657,"domain_scores_codex":[0.9996096,0.0001333336,0.00003355477,0.0001370807,0.00003871121,0.00004759685],"domain_scores_gemma":[0.9992105,0.0002394819,0.0003202563,0.00009654836,0.00005293411,0.00008024211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001605342,0.00001870208,0.9962003,0.00001328984,0.0002521188,0.0001007801,0.0001001099,0.0001147157,0.001057831,0.00007947423,0.00006039033,0.001841741],"study_design_scores_gemma":[0.000003141415,0.00002206527,0.9993559,0.000004642834,0.00006187778,0.00007078981,0.00003994463,0.0002470358,0.00008047574,0.0000556206,0.0000573029,0.000001364898],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999091,0.000324995,0.0001806318,0.00005407133,0.000004112634,0.000002695102,0.0001548682,0.000004942829,0.0001826027],"genre_scores_gemma":[0.9995587,0.00007627963,0.0001582191,0.00001082076,0.000004018916,0.000003324054,0.0001024606,0.000002632662,0.00008340417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01094086,"threshold_uncertainty_score":0.02175432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08025349275704259,"score_gpt":0.2969488365548447,"score_spread":0.2166953437978021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}