{"id":"W4327572236","doi":"10.1016/j.cbi.2023.110452","title":"Ursonic acid from Artemisia montana exerts anti-diabetic effects through anti-glycating properties, and by inhibiting PTP1B and activating the PI3K/Akt signaling pathway in insulin-resistant C2C12 cells","year":2023,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Phytochemicals and Antioxidant Activities","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Chemistry; IC50; Protein kinase B; Ursolic acid; Docking (animal); Glucose uptake; PI3K/AKT/mTOR pathway; Biochemistry; Insulin; Chinese hamster ovary cell; Pharmacology; Signal transduction; Biology; Receptor; In vitro; Endocrinology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007556806,0.0003334676,0.0002876088,0.000517484,0.0002826168,0.0002046961,0.0001074736,0.0002496728,0.001053749],"category_scores_gemma":[0.00008508175,0.0001031671,0.0003048507,0.0002707194,0.0001601845,0.000200155,0.0001824976,0.0003759332,0.0001611028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00011309,"about_ca_system_score_gemma":0.0001505932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007308686,"about_ca_topic_score_gemma":0.00163772,"domain_scores_codex":[0.9999537,0.00001044398,0.000006299597,0.000008571473,0.00001037821,0.00001054562],"domain_scores_gemma":[0.9999608,0.000006484712,0.0000101295,0.000004653192,0.0000069874,0.0000108953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004193979,0.00004066249,0.0002742294,0.00009202816,0.00002382638,0.0001106109,0.00002120151,0.00003977896,0.9947507,0.00007868539,0.00005691317,0.004091963],"study_design_scores_gemma":[0.0000622991,0.0005569133,0.008465893,0.00001442378,0.0001326037,0.0003616276,0.00003361769,0.0003037587,0.9852203,0.00008779961,0.004751513,0.000009344736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891707,0.006212141,0.001497581,0.0001948681,0.00005707773,0.00001770676,0.0002666792,0.00008464883,0.002498627],"genre_scores_gemma":[0.994169,0.001888044,0.0009551532,0.00009982511,0.00003104399,0.000009998446,0.0004357974,0.00001227959,0.002398863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001053749,"threshold_uncertainty_score":0.003525138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03935312715025258,"score_gpt":0.2565775909067985,"score_spread":0.217224463756546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}