{"id":"W4327572236","doi":"10.1016/j.cbi.2023.110452","title":"Ursonic acid from Artemisia montana exerts anti-diabetic effects through anti-glycating properties, and by inhibiting PTP1B and activating the PI3K/Akt signaling pathway in insulin-resistant C2C12 cells","year":2023,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Phytochemicals and Antioxidant Activities","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Chemistry; IC50; Protein kinase B; Ursolic acid; Docking (animal); Glucose uptake; PI3K/AKT/mTOR pathway; Biochemistry; Insulin; Chinese hamster ovary cell; Pharmacology; Signal transduction; Biology; Receptor; In vitro; Endocrinology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002316442,0.0003388744,0.0005975309,0.00006688236,0.0003179402,0.0001086281,0.0001184148,0.0001850961,0.00002071571],"category_scores_gemma":[0.0006482311,0.0002224715,0.0000970237,0.000364884,0.0002674548,0.0003075001,0.0001984699,0.0007782823,0.000006647491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009534255,"about_ca_system_score_gemma":0.00004150063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001487255,"about_ca_topic_score_gemma":0.00000445333,"domain_scores_codex":[0.9980882,0.00009902353,0.0005150034,0.0006146637,0.0001649636,0.0005181508],"domain_scores_gemma":[0.9981769,0.001228777,0.0002276534,0.0002017696,0.00005025927,0.0001146227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006292269,0.000128949,0.002136177,0.0001396578,0.00005375829,0.00003315358,0.0009101108,0.000003223746,0.9945821,0.00001329061,0.0001950001,0.001741667],"study_design_scores_gemma":[0.0007137569,0.0000946165,0.002466179,0.001684245,0.00003096462,0.00002882275,0.002221483,0.0004781196,0.9914122,0.0002359297,0.0003567833,0.0002769554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957913,0.002323384,0.00002969807,0.0007891965,0.0001083193,0.0004804978,0.00004400998,0.0001710158,0.000262562],"genre_scores_gemma":[0.9986568,0.0003630817,0.0001906591,0.0003232342,0.0001837846,0.0001078744,0.00008222491,0.00003344599,0.00005886812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003169946,"threshold_uncertainty_score":0.9072126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03935312715025258,"score_gpt":0.2565775909067985,"score_spread":0.217224463756546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}