{"id":"W4327587428","doi":"10.30574/wjbphs.2023.13.3.0111","title":"Protective effects of Auranofin on the 6-hydroxydopamine model of Parkinson's disease in rats","year":2023,"lang":"en","type":"article","venue":"World Journal of Biology Pharmacy and Health Sciences","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Neuroprotection; Parkinson's disease; Nitric oxide synthase; Dopamine; KEAP1; Pharmacology; Auranofin; Striatum; Hydroxydopamine; Chemistry; Nitric oxide; Metabolite; Internal medicine; Medicine; Endocrinology; Biochemistry; Disease; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009321381,0.0004952233,0.0005016307,0.0005050345,0.0002260392,0.000131987,0.0001957411,0.0003761576,0.001403245],"category_scores_gemma":[0.00006865097,0.0001648286,0.0003114417,0.000158458,0.0002280888,0.0002743759,0.0001542311,0.0005572461,0.0001627094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001613429,"about_ca_system_score_gemma":0.0002017168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001003783,"about_ca_topic_score_gemma":0.001616229,"domain_scores_codex":[0.9999475,0.000006547064,0.000004064125,0.00001248965,0.00001060765,0.00001873092],"domain_scores_gemma":[0.9999251,0.000004693578,0.00002105609,0.000005375151,0.00001065975,0.00003313634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002856439,0.0007413513,0.000610724,0.0001935432,0.00003962455,0.0002027326,0.00004563612,0.0001873088,0.9868645,0.00009564999,0.0001757093,0.007986744],"study_design_scores_gemma":[0.000284808,0.0163366,0.0138917,0.00004541357,0.000147278,0.0005267906,0.00009410288,0.00106469,0.9643229,0.0001535381,0.003107256,0.00002486297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946339,0.003285147,0.0005917911,0.0001503672,0.00005240442,0.00003290776,0.0002100683,0.00009193982,0.0009513575],"genre_scores_gemma":[0.9943001,0.00242016,0.0008516357,0.00008127477,0.00001830692,0.00003642671,0.000279193,0.000007012837,0.002006001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001403245,"threshold_uncertainty_score":0.004694343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06931297543070235,"score_gpt":0.3792747351900846,"score_spread":0.3099617597593822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}