{"id":"W4327591598","doi":"10.1038/s41467-023-37205-5","title":"B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Benoziyo Endowment Fund for the Advancement of Science; Azrieli Foundation; Israel Science Foundation; Gerald O. Mann Charitable Foundation; European Molecular Biology Organization","keywords":"Immunoglobulin class switching; DYRK1A; Germinal center; Biology; Phosphorylation; Cell biology; Isotype; B cell; Antibody; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001451552,0.0003008922,0.0002002726,0.0001954875,0.0001760839,0.000410122,0.0001908197,0.0002263156,0.001172202],"category_scores_gemma":[0.0001360618,0.0001410562,0.0001771899,0.0001111865,0.0002571282,0.0002224193,0.0002542264,0.0003318331,0.0006359012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003732523,"about_ca_system_score_gemma":0.0001340193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002653504,"about_ca_topic_score_gemma":0.0003704638,"domain_scores_codex":[0.9998633,0.00001997911,0.00001366251,0.00004189614,0.00003140064,0.00002972635],"domain_scores_gemma":[0.999859,0.00001273301,0.00007743756,0.000009475663,0.000009018669,0.0000322568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001036765,0.000008310391,0.0003440363,0.00001988787,0.000003880761,0.00006713278,0.000006886357,0.00007363522,0.998362,0.0001435335,0.00004464311,0.0008223351],"study_design_scores_gemma":[0.00001738073,0.00008021218,0.009440234,0.000004223752,0.000007385875,0.0005268909,0.00001995272,0.001024275,0.9867935,0.0001193201,0.001960687,0.000005948145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931332,0.002009674,0.00225861,0.0001926971,0.00003138047,0.00001146671,0.0004001048,0.0001367981,0.001826072],"genre_scores_gemma":[0.9974347,0.0005412792,0.0007151992,0.0000253516,0.000008086036,0.000008194166,0.0002526956,0.00001631774,0.0009981953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001172202,"threshold_uncertainty_score":0.003921449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01271156188513688,"score_gpt":0.280386109078395,"score_spread":0.2676745471932581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}