{"id":"W4327599808","doi":"10.3390/pharmaceutics15030958","title":"The Hedgehog Pathway as a Therapeutic Target in Chronic Myeloid Leukemia","year":2023,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Leukemia and Lymphoma Society of Canada","keywords":"Smoothened; Hedgehog; Myeloid leukemia; Cancer research; Hedgehog signaling pathway; Biology; Leukemia; Myeloid; Signal transduction; Immunology; Bioinformatics; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009666523,0.0007012474,0.001016465,0.0001305831,0.0002991494,0.00008340942,0.0009589918,0.0004944047,0.00001530274],"category_scores_gemma":[0.0002098683,0.000503296,0.0005316272,0.0005313442,0.0002487828,0.000003079626,0.0005474137,0.0008396102,0.0005709621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006262001,"about_ca_system_score_gemma":0.002584829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000013956,"about_ca_topic_score_gemma":0.00006242946,"domain_scores_codex":[0.9967579,0.0004534855,0.0008200036,0.0007618849,0.0003099387,0.000896836],"domain_scores_gemma":[0.9984014,0.0002614005,0.0003212634,0.0007943833,0.00008176174,0.0001397977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002553482,0.00003655697,0.000007846296,0.006598361,0.001044153,0.00008300524,0.0001174936,0.000104808,0.002632901,0.0001526031,0.001537944,0.9876588],"study_design_scores_gemma":[0.0003444237,0.00010013,0.000001241625,0.001394446,0.0002443069,0.00002843212,0.00003741726,0.00007740036,0.002376069,0.0001156414,0.9947212,0.0005592574],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000838961,0.9969777,0.00003209518,0.0000537461,0.0008270068,0.00104445,0.00008415965,0.00007212128,0.0008247627],"genre_scores_gemma":[0.0002821721,0.9942634,0.00002367841,0.000214331,0.001084989,0.000453882,0.0002274831,0.0002130137,0.003237106],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9931833,"threshold_uncertainty_score":0.9997419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1142896494901298,"score_gpt":0.4073052567402137,"score_spread":0.2930156072500839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}