{"id":"W4327606736","doi":"10.1016/j.eclinm.2023.101897","title":"Napabucasin plus nab-paclitaxel with gemcitabine versus nab-paclitaxel with gemcitabine in previously untreated metastatic pancreatic adenocarcinoma: an adaptive multicentre, randomised, open-label, phase 3, superiority trial","year":2023,"lang":"en","type":"article","venue":"EClinicalMedicine","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Gemcitabine; Hazard ratio; Nab-paclitaxel; Internal medicine; Pancreatic cancer; Oncology; Clinical endpoint; Adenocarcinoma; Gastroenterology; Confidence interval; Cancer; Clinical trial","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003978248,0.001045588,0.002618856,0.00047939,0.0005229041,0.0001180827,0.001096513,0.0004496541,0.001259027],"category_scores_gemma":[0.001579935,0.0007506392,0.0001743973,0.001963447,0.001369759,0.0006801926,0.0003673018,0.001953919,0.0002072664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004149642,"about_ca_system_score_gemma":0.0009468113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008048111,"about_ca_topic_score_gemma":0.001280732,"domain_scores_codex":[0.9913726,0.002605674,0.001911934,0.001666921,0.0007670134,0.001675819],"domain_scores_gemma":[0.9922812,0.004469293,0.0007053327,0.0009393541,0.0004270264,0.001177768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9566576,0.01099268,0.017107,0.0002281121,0.002312724,0.004183297,0.00194589,0.0001337863,0.0006929024,0.000235071,0.001732684,0.003778195],"study_design_scores_gemma":[0.9221907,0.04119284,0.009143434,0.0004388755,0.003096746,0.00009803833,0.002841984,0.01624391,0.0002191164,0.00009591656,0.003382073,0.001056407],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985607,0.001597927,0.0001256637,0.001659562,0.001577662,0.00764781,0.0003348282,0.000295839,0.001153717],"genre_scores_gemma":[0.9930683,0.0009280046,0.001402742,0.0009585384,0.0007478513,0.000802004,0.0007387614,0.0001457841,0.001207958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.034467,"threshold_uncertainty_score":0.9996539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.386636987915397,"score_gpt":0.5231980314798126,"score_spread":0.1365610435644156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}