{"id":"W4327606736","doi":"10.1016/j.eclinm.2023.101897","title":"Napabucasin plus nab-paclitaxel with gemcitabine versus nab-paclitaxel with gemcitabine in previously untreated metastatic pancreatic adenocarcinoma: an adaptive multicentre, randomised, open-label, phase 3, superiority trial","year":2023,"lang":"en","type":"article","venue":"EClinicalMedicine","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Gemcitabine; Hazard ratio; Nab-paclitaxel; Internal medicine; Pancreatic cancer; Oncology; Clinical endpoint; Adenocarcinoma; Gastroenterology; Confidence interval; Cancer; Clinical trial","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001749299,0.001301605,0.002150363,0.0003061348,0.0002965341,0.0009951091,0.0007766726,0.001228885,0.003736341],"category_scores_gemma":[0.001531569,0.0004082338,0.001630904,0.0004063747,0.000984112,0.0009691405,0.0004100427,0.001986394,0.0005631786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009830485,"about_ca_system_score_gemma":0.0009995322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008622647,"about_ca_topic_score_gemma":0.00225751,"domain_scores_codex":[0.9994872,0.0002954124,0.00002854439,0.0000855843,0.00003931428,0.00006386378],"domain_scores_gemma":[0.9992512,0.0001889732,0.0001929151,0.00006612801,0.00004518717,0.00025551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9832937,0.003188283,0.0006764586,0.0002991938,0.0005694017,0.00003575123,0.0000469713,0.0003118351,0.002053184,0.00005273807,0.0003425753,0.00912991],"study_design_scores_gemma":[0.911108,0.08426765,0.002679955,0.00003350733,0.0003897576,0.00005429635,0.00002479253,0.0004368397,0.0002967774,0.0001354069,0.0005608443,0.0000122244],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941201,0.002953772,0.0001680403,0.0003098602,0.0002068315,0.001060602,0.0003903625,0.00003511743,0.0007553578],"genre_scores_gemma":[0.992951,0.001830894,0.000780357,0.0005804624,0.000241466,0.001471016,0.0008429954,0.00001414021,0.001287683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003736341,"threshold_uncertainty_score":0.01249933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.386636987915397,"score_gpt":0.5231980314798126,"score_spread":0.1365610435644156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}