{"id":"W4327614603","doi":"10.1101/2023.03.15.532626","title":"CRAPS: Chromosomal-Repair-Assisted Pathway Shuffling in yeast","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"","keywords":"Metabolic engineering; Biology; Metabolic pathway; Computational biology; Synthetic biology; Gene; Yeast; Genetics; Saccharomyces cerevisiae","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004587153,0.0009815501,0.0004719572,0.0006050679,0.0003292795,0.0006964958,0.000754323,0.0003142447,0.001990749],"category_scores_gemma":[0.0005442387,0.0003962759,0.0005760391,0.0005456247,0.000394203,0.000271152,0.0009879175,0.0009857786,0.001013269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004826696,"about_ca_system_score_gemma":0.0006847956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003324257,"about_ca_topic_score_gemma":0.002613781,"domain_scores_codex":[0.9997755,0.00002591878,0.00001687108,0.00006661769,0.00007844865,0.00003666334],"domain_scores_gemma":[0.9997686,0.00005252195,0.00004095809,0.00006926467,0.00002220168,0.00004645703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00133625,0.0002964288,0.0027881,0.0003698954,0.0001744273,0.0004427345,0.0001317197,0.02429559,0.9102356,0.003117127,0.00531041,0.05150171],"study_design_scores_gemma":[0.0002680176,0.0004347236,0.0026451,0.00004018655,0.00004697549,0.0004594366,0.00006576088,0.1141491,0.8565557,0.00106908,0.02417868,0.00008722991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6656113,0.0009791878,0.2292013,0.000303914,0.0001924489,0.0005197653,0.006881679,0.09234505,0.003965419],"genre_scores_gemma":[0.7985188,0.0008978911,0.1813848,0.0001222748,0.00002283513,0.0004613672,0.009341533,0.003598327,0.005652273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003324257,"threshold_uncertainty_score":0.006659687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0175296980484952,"score_gpt":0.2158129482119952,"score_spread":0.1982832501635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}