{"id":"W4327616865","doi":"10.3389/fimmu.2023.1020134","title":"DNA lipid nanoparticle vaccine targeting outer surface protein C affords protection against homologous Borrelia burgdorferi needle challenge in mice","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Vector-borne infectious diseases","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; University of Calgary; National Research Council Canada; University of Ottawa; Health Canada","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Health Canada; Government of Canada","keywords":"Borrelia burgdorferi; Lyme disease; Virology; Vaccination; DNA vaccination; Medicine; Microbiology; Immunology; Antibody; Biology; Immunization","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001826712,0.0005433759,0.0002848773,0.0003927638,0.0001231908,0.0002523792,0.0002027274,0.0007184367,0.0007301307],"category_scores_gemma":[0.0001235204,0.0001758331,0.0002510489,0.0001233348,0.0002533201,0.0002817524,0.0001472397,0.0006038336,0.0002573644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002543142,"about_ca_system_score_gemma":0.0002587484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005003649,"about_ca_topic_score_gemma":0.0005897586,"domain_scores_codex":[0.9998717,0.00001342922,0.000008717961,0.00003358131,0.00003121191,0.00004131036],"domain_scores_gemma":[0.9999113,0.00001276872,0.00002919244,0.000008580481,0.0000142273,0.00002396278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002210927,0.0001356571,0.00005886342,0.00006560479,0.00000565137,0.0000201718,0.00001643963,0.0001797445,0.9974655,0.00007856885,0.000063199,0.001689443],"study_design_scores_gemma":[0.00008516487,0.003321321,0.0009953554,0.0000192121,0.00002798419,0.00009448719,0.00002056266,0.001501733,0.9918364,0.00006758094,0.002023028,0.000007177934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911386,0.001346874,0.004917394,0.00021384,0.00008004468,0.00007626839,0.0003177392,0.0001934335,0.001715861],"genre_scores_gemma":[0.9914775,0.001209153,0.003623769,0.000101131,0.00002386996,0.00009068569,0.0004175195,0.00002387033,0.003032485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007301307,"threshold_uncertainty_score":0.002442539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00865502622379453,"score_gpt":0.2127954395269946,"score_spread":0.2041404133032001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}