{"id":"W4327616865","doi":"10.3389/fimmu.2023.1020134","title":"DNA lipid nanoparticle vaccine targeting outer surface protein C affords protection against homologous Borrelia burgdorferi needle challenge in mice","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Vector-borne infectious diseases","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; University of Calgary; National Research Council Canada; University of Ottawa; Health Canada","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Health Canada; Government of Canada","keywords":"Borrelia burgdorferi; Lyme disease; Virology; Vaccination; DNA vaccination; Medicine; Microbiology; Immunology; Antibody; Biology; Immunization","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006475176,0.0004205659,0.0007086411,0.0006950276,0.0002218987,0.00002407782,0.0004371846,0.0007109035,0.000130871],"category_scores_gemma":[0.0004022704,0.0004473102,0.0001340354,0.001164564,0.0002320608,0.0002535947,0.0002785393,0.0008899317,0.0006686213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003878389,"about_ca_system_score_gemma":0.0001310313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009176701,"about_ca_topic_score_gemma":0.0004578709,"domain_scores_codex":[0.9964307,0.0007353805,0.0007634265,0.0007612297,0.00006252887,0.001246712],"domain_scores_gemma":[0.9990945,0.00007223139,0.0002354927,0.0004710139,0.00008863903,0.00003810862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009650951,0.0006060372,0.02569515,0.00006771691,0.0003084806,0.0001565628,0.001502552,0.000715468,0.9541402,0.00007995797,0.008914606,0.006848202],"study_design_scores_gemma":[0.01869634,0.003242436,0.1122296,0.0004965173,0.0001364777,0.0002205888,0.008363235,0.001683053,0.8024021,0.001903723,0.04797768,0.002648215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840023,0.007795434,0.000234013,0.001059215,0.004645245,0.00141043,0.00002665208,0.0005540028,0.0002727193],"genre_scores_gemma":[0.9973915,0.0004985874,0.0002278011,0.00008620232,0.00007266391,0.0004975847,0.0001510325,0.00007360633,0.00100103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1517381,"threshold_uncertainty_score":0.9997979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00865502622379453,"score_gpt":0.2127954395269946,"score_spread":0.2041404133032001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}