{"id":"W4327622012","doi":"10.3390/cells12060914","title":"Molecular Analysis of the Superior Efficacy of a Dual Epidermal Growth Factor Receptor (EGFR)-DNA-Targeting Combi-Molecule in Comparison with Its Putative Prodrugs 6-Mono-Alkylamino- and 6,6-Dialkylaminoquinazoline in a Human Osteosarcoma Xenograft Model","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Fondation du cancer des Cèdres; McGill University Health Centre; McGill University","keywords":"In vivo; Quinazoline; Epidermal growth factor receptor; Chemistry; DNA; DNA damage; Western blot; Cancer research; Molecular biology; Pharmacology; Receptor; Biology; Biochemistry; Stereochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002853737,0.0003069766,0.0008469688,0.0003737301,0.00009206128,0.0000254694,0.0003292121,0.0001382012,0.00004544314],"category_scores_gemma":[0.00009827157,0.0002518111,0.0001888985,0.001701126,0.000243905,0.00007824083,0.0002013317,0.0002854396,0.000003051261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006011041,"about_ca_system_score_gemma":0.00008016466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001646915,"about_ca_topic_score_gemma":0.00009133587,"domain_scores_codex":[0.9976638,0.0001193862,0.0008812176,0.0005384557,0.0003513689,0.0004457838],"domain_scores_gemma":[0.9986317,0.0003087372,0.0004151672,0.0004226861,0.0001337654,0.00008792218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006836324,0.0005328373,0.02114238,0.0002023632,0.0002009636,0.000007396942,0.004266927,0.007757467,0.9653472,0.0002701707,0.00001327232,0.000190647],"study_design_scores_gemma":[0.001187676,0.00004841104,0.02213862,0.0001134626,0.0002300904,6.042942e-7,0.001230383,0.04391046,0.9308469,0.0000272133,0.000006762574,0.0002594065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986467,0.0001500802,0.00004968591,0.0001743283,0.000008512645,0.0004418926,0.0002437231,0.0000363645,0.0002487313],"genre_scores_gemma":[0.9992945,0.00001751754,0.0003078499,0.00001474966,0.00001175874,0.0001016633,0.0001362315,0.0000430381,0.0000727406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03615299,"threshold_uncertainty_score":0.9999934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01634458860306775,"score_gpt":0.2645929604204509,"score_spread":0.2482483718173832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}