{"id":"W4327622012","doi":"10.3390/cells12060914","title":"Molecular Analysis of the Superior Efficacy of a Dual Epidermal Growth Factor Receptor (EGFR)-DNA-Targeting Combi-Molecule in Comparison with Its Putative Prodrugs 6-Mono-Alkylamino- and 6,6-Dialkylaminoquinazoline in a Human Osteosarcoma Xenograft Model","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Fondation du cancer des Cèdres; McGill University Health Centre; McGill University","keywords":"In vivo; Quinazoline; Epidermal growth factor receptor; Chemistry; DNA; DNA damage; Western blot; Cancer research; Molecular biology; Pharmacology; Receptor; Biology; Biochemistry; Stereochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001278409,0.0002324728,0.0002028889,0.0001689175,0.00005614763,0.0001095115,0.0001779619,0.0002265069,0.001061763],"category_scores_gemma":[0.00007277955,0.00007644951,0.000152394,0.0001564913,0.0001068175,0.0001532428,0.00003934153,0.0002730898,0.0001351677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000208104,"about_ca_system_score_gemma":0.0001032038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007840643,"about_ca_topic_score_gemma":0.0007349058,"domain_scores_codex":[0.9999424,0.000008973307,0.000004587446,0.0000130662,0.00001757837,0.00001348004],"domain_scores_gemma":[0.9999391,0.00001237819,0.00001599934,0.000005772713,0.0000102555,0.00001649708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003903809,0.0001269652,0.0001269034,0.00002954749,0.000007376608,0.00001908852,0.000007442472,0.0001921708,0.9979767,0.00003536891,0.00003994223,0.001048201],"study_design_scores_gemma":[0.00007023993,0.003999436,0.002939014,0.00000145827,0.00003329069,0.00009063425,0.00001214035,0.001698366,0.9905344,0.00001051451,0.0006068686,0.000003628337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99832,0.0003420287,0.0005503173,0.00002798348,0.00001130322,0.00001949379,0.0002606699,0.00002610823,0.0004420564],"genre_scores_gemma":[0.9969087,0.0003477891,0.001008571,0.00001365984,0.000005353619,0.00002887536,0.0004949796,0.00000574965,0.001186312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001061763,"threshold_uncertainty_score":0.00355196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01634458860306775,"score_gpt":0.2645929604204509,"score_spread":0.2482483718173832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}