{"id":"W4327654302","doi":"10.1007/978-3-031-21054-9_14","title":"Monoamine Oxidase B (MAO-B): A Target for Rational Drug Development in Schizophrenia Using PET Imaging as an Example","year":2023,"lang":"en","type":"review","venue":"Advances in neurobiology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Centre for Addiction and Mental Health; University of Toronto; Douglas Mental Health University Institute; McGill University; Douglas College","funders":"","keywords":"Monoamine oxidase B; Schizophrenia (object-oriented programming); Monoamine oxidase; Positron emission tomography; Psychology; Neuroscience; Psychosis; Dopamine; Drug development; Psychiatry; Medicine; Pharmacology; Drug; Biology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004471959,0.0007359835,0.001472796,0.0009604243,0.0001661745,0.00006506802,0.001039436,0.0001227436,0.00005006337],"category_scores_gemma":[0.0003925208,0.0007152483,0.0002000131,0.001018807,0.0002654445,0.0008002791,0.0002232956,0.0007434597,0.00009546285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002419747,"about_ca_system_score_gemma":0.0005740264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004545112,"about_ca_topic_score_gemma":0.0002091219,"domain_scores_codex":[0.9946236,0.0008642034,0.00143612,0.001935775,0.0002139542,0.0009263356],"domain_scores_gemma":[0.9976652,0.001093168,0.000528579,0.0005396818,0.00004142199,0.0001320058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003122489,0.0008082891,0.0004400723,0.008155399,0.00001449523,0.001896815,0.0005344218,0.001172152,0.02933611,0.002102777,0.0000410511,0.9551862],"study_design_scores_gemma":[0.001495138,0.0001512757,0.00003811872,0.003033614,0.00005432337,0.0005672488,0.00001689276,0.0002694879,0.003809385,0.001006013,0.9882872,0.001271275],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2125998,0.7723518,0.0004688846,0.00009309105,0.004334655,0.009009467,0.0005176662,0.0005670887,0.00005753459],"genre_scores_gemma":[0.001767827,0.982936,0.01081831,0.0006257905,0.0002127508,0.002797953,0.0003830931,0.000333056,0.0001252341],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9882462,"threshold_uncertainty_score":0.9995298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1050621657955921,"score_gpt":0.389900745743989,"score_spread":0.2848385799483969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}